Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | BRD2 | P25440 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | FABP3 | P05413 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8006796 | 0.88 | CHEK1 (0.51) | GAACASP3BRD4MEN1KMT2A | |
| SCHEMBL8006987 | 0.80 | TDP2 (0.48) | CHEK1 | |
| SCHEMBL7886526 | 0.71 | CASP3 (0.41) | MAPTGAAKDM4ETHRBTDP1 | |
| SCHEMBL7886522 | 0.71 | CHRM2 (0.44) | MAPTGAAKDM4ETHRBTDP1 | |
| SCHEMBL11411139 | 0.71 | MAOA (0.61) | MAPTCASP3SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9260410 | 0.70 | RXRA (0.66) | MAPTGAAKDM4ETHRBTDP1 | |
| SCHEMBL29426410 | 0.70 | RXRA (0.66) | MAPTGAAKDM4ETHRBTDP1 | |
| SCHEMBL10911536 | 0.69 | GSK3B (0.41) | GAAKDM4ECASP3CHEK1HSD17B10 | |
| SCHEMBL7399139 | 0.68 | DDB1 (0.46) | MAPTGAAKDM4ETHRBTDP1 | |
| SCHEMBL29012837 | 0.68 | RXRA (0.64) | MAPTGAAKDM4ETHRBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000021910-A2 | 1,2-DISUBSTITUTED CYCLOPROPANES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2000-04-20 | — | — | WO | disclosed |