Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.41 |
| ▸ | CCR1 | P32246 | 4/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7995251 | 0.83 | TRPV4 (0.45) | TRPV4CTSK | |
| SCHEMBL8005433 | 0.83 | TRPV4 (0.61) | TRPV4CCR1CTSK | |
| SCHEMBL8008195 | 0.83 | TRPV4 (0.43) | TRPV4 | |
| SCHEMBL8004208 | 0.83 | TRPV4 (0.43) | TRPV4CCR1 | |
| SCHEMBL4059005 | 0.82 | TRPV4 (0.42) | TRPV4CCR1CA1CA2CTSK | |
| SCHEMBL8005363 | 0.72 | PYGL (0.41) | — | |
| SCHEMBL4053067 | 0.69 | TRPV4 (0.46) | TRPV4CCR1CA1CA2CTSK | |
| SCHEMBL8006947 | 0.65 | TRPV4 (0.45) | TRPV4CCR1CA1CA2CTSK | |
| SCHEMBL4049707 | 0.65 | TRPV4 (0.45) | TRPV4CCR1 | |
| SCHEMBL4051481 | 0.65 | TRPV4 (0.64) | TRPV4CCR1CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |