Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 5/20 | 0.42 |
| ▸ | CCR1 | P32246 | 4/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 4/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 3/20 | 0.31 |
| ▸ | BCL2 | P10415 | 1/20 | 0.31 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | GRN | P28799 | 1/20 | 0.31 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 2/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | ITGAV | P06756 | 1/20 | 0.31 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4053067 | 0.86 | TRPV4 (0.46) | TRPV4CCR1CA1CA2CTSK | |
| SCHEMBL8007072 | 0.82 | TRPV4 (0.41) | TRPV4CCR1CA1CA2CTSK | |
| SCHEMBL4054443 | 0.82 | TRPV4 (0.46) | TRPV4CTSKCTSLCTSSCTSB | |
| SCHEMBL4049334 | 0.82 | TRPV4 (0.64) | TRPV4CCR1CTSKCTSSCTSB | |
| SCHEMBL4051572 | 0.82 | TRPV4 (0.64) | TRPV4CCR1CTSKCTSSCTSB | |
| SCHEMBL19856860 | 0.82 | TRPV4 (0.64) | TRPV4CCR1CTSKCTSSCTSB | |
| SCHEMBL4051481 | 0.82 | TRPV4 (0.64) | TRPV4CCR1CTSKCTSSCTSB | |
| SCHEMBL4049707 | 0.82 | TRPV4 (0.45) | TRPV4CCR1CTSLCTSS | |
| SCHEMBL4056496 | 0.82 | TAS1R3 (0.46) | TRPV4CTSKCTSLCTSS | |
| SCHEMBL4051232 | 0.81 | TRPV4 (0.49) | TRPV4CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | claimed |
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |