Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 10/20 | 0.50 |
| ▸ | TEK | Q02763 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8011827 | 0.91 | KDM4E (0.44) | ESR1TEKKDM4ETSHRLMNA | |
| SCHEMBL8011287 | 0.87 | TEK (0.43) | ESR1TEKKDM4ETSHRLMNA | |
| SCHEMBL22219425 | 0.84 | FAAH (0.49) | TSHRTP53 | |
| SCHEMBL8008240 | 0.82 | KDM4E (0.63) | TEKKDM4ETSHRLMNANPSR1 | |
| SCHEMBL4422948 | 0.76 | MLYCD (0.43) | MAPK13MAPK12MAPK11MAPK14KDM4E | |
| SCHEMBL18152846 | 0.75 | TSHR (0.61) | KDM4ETSHRHSD17B10TP53CYP1A2 | |
| SCHEMBL8797582 | 0.75 | ALDH1A1 (0.53) | KDM4ELMNANPSR1HSD17B10TP53 | |
| SCHEMBL7996428 | 0.74 | KDM4E (0.53) | TEKKDM4ETSHRLMNANPSR1 | |
| SCHEMBL27237042 | 0.74 | FAAH (0.42) | TP53MAPTADORA2BGAA | |
| SCHEMBL8113557 | 0.74 | FAAH (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000019994-A9 | ESTROGEN RECEPTOR LIGANDS | UNIV ILLINOIS (US) | 2000-08-31 | — | — | WO | disclosed |
| WO-2000019994-A1 | ESTROGEN RECEPTOR LIGANDS | BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2000-04-13 | — | — | WO | disclosed |