Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.49 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8021703 | 0.94 | L3MBTL1 (0.47) | L3MBTL1NPC1RAB9ASMN1; SMN2HDAC3 | |
| SCHEMBL27452028 | 0.88 | HTT (0.57) | L3MBTL1NPC1RAB9ASMN1; SMN2HDAC3 | |
| SCHEMBL10126727 | 0.84 | POLB (0.53) | L3MBTL1NPC1RAB9ASMN1; SMN2HDAC3 | |
| SCHEMBL12172265 | 0.84 | HTT (0.62) | L3MBTL1NPC1RAB9ASMN1; SMN2HDAC3 | |
| SCHEMBL14280004 | 0.82 | ALOX15 (0.50) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL11230329 | 0.82 | KDM4E (0.63) | L3MBTL1NPC1RAB9AHDAC3HDAC1 | |
| SCHEMBL3106472 | 0.81 | CRBN (0.46) | NPC1RAB9ASMN1; SMN2HDAC3HDAC1 | |
| SCHEMBL31203044 | 0.81 | SMN1; SMN2 (0.74) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL9419699 | 0.80 | MAPK1 (0.65) | L3MBTL1NPC1RAB9AHDAC3HDAC1 | |
| SCHEMBL14097385 | 0.80 | MAPK1 (0.65) | L3MBTL1NPC1RAB9AHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763016-B1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL MEDIATED CONDITIONS | AXYS PHARM INC (US) | 2000-01-26 | — | — | EP | claimed |
| US-5656660-A | AMINE OR GUANIDINE GROUP-CONTAINING TRYPTASE INHIBITOR | ARRIS PHARMACEUTICAL CORPORATION (US) | 1997-08-12 | — | — | US | claimed |