Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | NOS1 | P29475 | 2/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.35 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8007754 | 0.98 | PKM (0.42) | PKMMAPTPRMT6SLC6A3NOS1 | |
| SCHEMBL8010413 | 0.97 | PKM (0.41) | PKMMAPTPRMT6SLC6A3TP53 | |
| SCHEMBL7998569 | 0.97 | PKM (0.41) | PKMMAPTPRMT6SLC6A3TP53 | |
| SCHEMBL8010415 | 0.87 | PRMT6 (0.35) | PKMMAPTPRMT6SLC6A3TP53 | |
| SCHEMBL7998573 | 0.82 | PRMT6 (0.36) | MAPTPRMT6TP53BACE1LMNA | |
| SCHEMBL7998514 | 0.81 | PKM (0.38) | PKMMAPTSLC6A3SMN1; SMN2GAA | |
| SCHEMBL7998468 | 0.80 | PKM (0.37) | PKMMAPTSLC6A3SMN1; SMN2GAA | |
| SCHEMBL7998465 | 0.78 | PKM (0.39) | PKMMAPTSLC6A3SMN1; SMN2GAA | |
| SCHEMBL8009767 | 0.77 | L3MBTL1 (0.38) | PKMMAPTPRMT6SLC6A3LMNA | |
| SCHEMBL10260842 | 0.76 | SLC6A3 (0.38) | MAPTSLC6A3NOS1NOS3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009134987-A1 | DIFLUOROMETHYL-CONTAINING MACROCYCLIC COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS | ENANTA PHARMACEUTICALS, INC. (US) | 2009-11-05 | — | — | WO | disclosed |