Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CMA1 | P23946 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | F11 | P03951 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8008968 | 0.93 | HPGD (0.39) | KMT2AMEN1ALDH1A1MAPTGAA | |
| SCHEMBL8011512 | 0.91 | MEN1 (0.39) | KMT2AMEN1ALDH1A1MAPTGAA | |
| SCHEMBL7999795 | 0.88 | TP53 (0.38) | KMT2AMEN1ALDH1A1GAAKAT8 | |
| SCHEMBL8008606 | 0.86 | KDM4E (0.35) | KMT2AMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL8009344 | 0.84 | MAPT (0.43) | KMT2AMEN1ALDH1A1MAPTGAA | |
| SCHEMBL8427443 | 0.84 | ALDH1A1 (0.33) | KMT2AMEN1ALDH1A1MAPTGAA | |
| SCHEMBL6944940 | 0.83 | ALDH1A1 (0.43) | KMT2AMEN1ALDH1A1MAPTGAA | |
| SCHEMBL6944935 | 0.83 | ALDH1A1 (0.43) | KMT2AMEN1ALDH1A1MAPTGAA | |
| SCHEMBL8009329 | 0.82 | SHMT2 (0.37) | KMT2AALDH1A1MAPTPKMHPGD | |
| SCHEMBL8008612 | 0.80 | KMT2A (0.37) | KMT2AMEN1ALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6034099-A | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones | CELL PATHWAYS, INC. (US) | 2000-03-07 | — | — | US | claimed |
| US-6034099-A | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones | CELL PATHWAYS, INC. (US) | 2000-03-07 | — | — | US | disclosed |