Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KAT8 | Q9H7Z6 | 3/20 | 0.34 |
| ▸ | DDX3X | O00571 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8009134 | 0.91 | PLA2G7 (0.34) | KDM4EHTTNPSR1PTGS1ALDH1A1 | |
| SCHEMBL8011512 | 0.88 | MEN1 (0.39) | KDM4EHTTNPSR1KAT8ALDH1A1 | |
| SCHEMBL8008615 | 0.86 | KMT2A (0.35) | HTTKAT8ALDH1A1HPGDMAPT | |
| SCHEMBL8009329 | 0.85 | SHMT2 (0.37) | HTTALDH1A1HPGDMAPTKMT2A | |
| SCHEMBL8008968 | 0.84 | HPGD (0.39) | KDM4ENPSR1KAT8ALDH1A1HPGD | |
| SCHEMBL7999795 | 0.84 | TP53 (0.38) | HTTKAT8DDX3XALDH1A1MEN1 | |
| SCHEMBL8009344 | 0.84 | MAPT (0.43) | KDM4EHTTNPSR1KAT8ALDH1A1 | |
| SCHEMBL6953049 | 0.83 | ALDH1A1 (0.39) | KDM4EGLAHTTNPSR1KAT8 | |
| SCHEMBL6953052 | 0.83 | ALDH1A1 (0.39) | KDM4EGLAHTTNPSR1KAT8 | |
| SCHEMBL8008599 | 0.80 | KMT2A (0.34) | KDM4EKAT8DDX3XPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6034099-A | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones | CELL PATHWAYS, INC. (US) | 2000-03-07 | — | — | US | claimed |
| US-6034099-A | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones | CELL PATHWAYS, INC. (US) | 2000-03-07 | — | — | US | disclosed |