Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | PPARA | Q07869 | 2/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14878570 | 0.88 | HDAC8 (0.53) | HDAC8LMNAHPGDPPARGPPARA | |
| SCHEMBL12139195 | 0.88 | HDAC8 (0.52) | HDAC8LMNAHPGDPPARGPPARA | |
| SCHEMBL12139167 | 0.84 | AKR1B10 (0.51) | HDAC8LMNAHPGDPPARGPPARA | |
| SCHEMBL8012083 | 0.78 | HDAC8 (0.50) | HDAC8PPARGPPARAPPARDGAA | |
| SCHEMBL13133475 | 0.77 | HPGD (0.55) | LMNAHPGDPPARGPPARAPPARD | |
| SCHEMBL4446937 | 0.71 | HPGD (0.52) | LMNAHPGDGAAKDM4EALDH1A1 | |
| SCHEMBL6927546 | 0.71 | GAA (0.65) | LMNAHPGDGAAKDM4EALDH1A1 | |
| SCHEMBL6141248 | 0.70 | FFAR1 (0.56) | HDAC8GAAHDAC1FFAR1KDM4E | |
| SCHEMBL95380 | 0.70 | HPGD (0.56) | LMNAHPGDPPARAPPARDGAA | |
| SCHEMBL8570550 | 0.70 | MEN1 (0.53) | LMNAHPGDPPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009092566-A1 | SUBSTITUTED AMINO-BENZIMIDAZOLES, MEDICAMENTS COMPRISING SAID COMPOUND, THEIR USE AND THEIR METHOD OF MANUFACTURE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-07-30 | — | — | WO | disclosed |