Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CDC25B | P30305 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32667936 | 0.89 | KDM4E (0.59) | MEN1KMT2AKDM4ETSHRMAPT | |
| SCHEMBL29191709 | 0.85 | MEN1 (0.62) | MEN1KMT2AKDM4ETSHRMAPT | |
| SCHEMBL8572013 | 0.82 | KDM4E (0.69) | KDM4EMAPTPLA2G2AHPGDPOLB | |
| SCHEMBL4276304 | 0.82 | ALDH1A1 (0.60) | MEN1KMT2APTGS2KDM4ETSHR | |
| SCHEMBL522526 | 0.81 | PTGS2 (0.55) | MEN1KMT2APTGS2KDM4ETSHR | |
| Diethyl Phthalate SCHEMBL11342742 | 0.80 | TSHR (0.78) | KMT2APTGS2KDM4ETSHRMAPT | |
| SCHEMBL15846567 | 0.80 | HPGD (0.51) | MEN1KMT2APTGS2KDM4ETSHR | |
| SCHEMBL2096332 | 0.79 | LMNA (0.57) | MEN1KMT2ATSHRMAPTHPGD | |
| SCHEMBL4273081 | 0.79 | ALDH1A1 (0.60) | MEN1KMT2AKDM4EMAPTHPGD | |
| SCHEMBL1127591 | 0.78 | KDM4E (0.69) | MEN1KMT2AKDM4ETSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739336-A | SELECTIVE 5-HYDROXYTRYPTAMINE-2C RECEPTOR ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1998-04-14 | — | — | US | disclosed |
| WO-1997000872-A1 | 1,3,8-TRIAZA- AND 3,8-DIAZA-1-OXASPIRO(4,5)DECANE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1997-01-09 | — | — | WO | disclosed |