Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | PPARG | P37231 | 4/20 | 0.48 |
| ▸ | PPARA | Q07869 | 4/20 | 0.48 |
| ▸ | PPARD | Q03181 | 3/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12139195 | 0.90 | HDAC8 (0.52) | HDAC8PPARGPPARAPPARDHDAC1 | |
| SCHEMBL14878570 | 0.78 | HDAC8 (0.53) | HDAC8PPARGPPARAPPARDHDAC1 | |
| SCHEMBL8009994 | 0.78 | HDAC8 (0.54) | HDAC8PPARGPPARAPPARDHDAC1 | |
| SCHEMBL8005946 | 0.76 | HIF1A (0.53) | HDAC8FFAR1 | |
| SCHEMBL12139167 | 0.74 | AKR1B10 (0.51) | HDAC8PPARGPPARAPPARDHTT | |
| SCHEMBL28138982 | 0.71 | MTNR1A (0.45) | HDAC8HDAC1HDAC2HTTKDM4E | |
| SCHEMBL6141248 | 0.71 | FFAR1 (0.56) | HDAC8HDAC1KDM4EALDH1A1FFAR1 | |
| SCHEMBL9674445 | 0.71 | AKR1C3 (0.49) | HDAC8HDAC1SMN1; SMN2KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL10430283 | 0.70 | MTNR1A (0.44) | HDAC8HDAC1HDAC2HTTKDM4E | |
| SCHEMBL6814420 | 0.70 | NCF1 (0.54) | HDAC1SMN1; SMN2MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009092566-A1 | SUBSTITUTED AMINO-BENZIMIDAZOLES, MEDICAMENTS COMPRISING SAID COMPOUND, THEIR USE AND THEIR METHOD OF MANUFACTURE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-07-30 | — | — | WO | disclosed |