Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.42 |
| ▸ | PDE4A | P27815 | 3/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ABHD16A | O95870 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8010890 | 0.84 | HRH1 (0.43) | NPC1RAB9AHRH1CYP1A2HPGD | |
| SCHEMBL8018544 | 0.82 | HRH1 (0.41) | SMN1; SMN2HRH1CYP1A2CYP2D6 | |
| SCHEMBL7998338 | 0.80 | CTSK (0.44) | HRH1CYP1A2LMNACYP2D6 | |
| SCHEMBL8008717 | 0.80 | KCNH2 (0.45) | CHRNB2CHRNA4HRH1CYP1A2CNR2 | |
| SCHEMBL8007360 | 0.79 | SIGMAR1 (0.51) | — | |
| SCHEMBL7999666 | 0.79 | HRH1 (0.43) | HRH1CYP1A2CYP2D6 | |
| SCHEMBL8010039 | 0.77 | HRH1 (0.42) | SMN1; SMN2HRH1CYP1A2MAPTLMNA | |
| SCHEMBL8010524 | 0.74 | SLC6A4 (0.41) | HRH1CYP1A2CYP2D6 | |
| SCHEMBL8020139 | 0.74 | HRH1 (0.43) | HRH1CYP1A2CYP2D6 | |
| SCHEMBL7998241 | 0.74 | P2RX7 (0.48) | HRH1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000027394-A1 | ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | UNIVERSITY COLLEGE LONDON (GB) | 2000-05-18 | — | — | WO | disclosed |