Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18598680 | 0.77 | MAPT (0.39) | ALDH1A1LMNAMAPTKDM4ECA12 | |
| SCHEMBL12985967 | 0.76 | ADRB2 (0.38) | ALDH1A1LMNAMAPTGAAKDM4E | |
| SCHEMBL8009795 | 0.73 | CA1 (0.35) | CA12CA1CA2CA9SIGMAR1 | |
| SCHEMBL7294193 | 0.72 | TSHR (0.43) | ALDH1A1LMNAMAPTCA12CA1 | |
| SCHEMBL28833363 | 0.71 | ALDH1A1 (0.48) | ALDH1A1LMNAMAPTGAAKDM4E | |
| SCHEMBL29950147 | 0.71 | NFKB1 (0.59) | ALDH1A1LMNAMAPTGAAKDM4E | |
| SCHEMBL3958499 | 0.71 | NFKB1 (0.59) | ALDH1A1LMNAMAPTGAAKDM4E | |
| SCHEMBL4556276 | 0.70 | TYR (0.39) | ALDH1A1LMNAMAPTGAAKDM4E | |
| SCHEMBL104124 | 0.69 | TYR (0.58) | ALDH1A1LMNAGAAKDM4ENFKB1 | |
| SCHEMBL170685 | 0.69 | NFKB1 (0.47) | ALDH1A1LMNAMAPTGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009112826-A1 | FURO [3, 2-B] PYRR0L-3-0NES AS CATHEPSIN S INHIBITORS | AMURA THERAPEUTICS LIMITED (GB) | 2009-09-17 | — | — | WO | disclosed |