Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | MDM4 | O15151 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8011684 | 1.00 | GAA (0.47) | GAATSHRAMY1AKMT2AL3MBTL1 | |
| SCHEMBL8425490 | 0.95 | GAA (0.43) | GAATSHRAMY1AKMT2AL3MBTL1 | |
| SCHEMBL8425491 | 0.95 | GAA (0.43) | GAATSHRAMY1AKMT2AL3MBTL1 | |
| SCHEMBL8425493 | 0.85 | GAA (0.46) | GAAAMY1AKMT2AL3MBTL1NPSR1 | |
| SCHEMBL8011329 | 0.84 | GAA (0.65) | GAAAMY1AKMT2AL3MBTL1NPSR1 | |
| SCHEMBL6945888 | 0.84 | GAA (0.65) | GAAAMY1AKMT2AL3MBTL1NPSR1 | |
| SCHEMBL8008711 | 0.83 | KAT8 (0.59) | GAAAMY1AKMT2AL3MBTL1MEN1 | |
| SCHEMBL6947870 | 0.83 | KAT8 (0.59) | GAAAMY1AKMT2AL3MBTL1MEN1 | |
| SCHEMBL6949903 | 0.83 | ALDH1A1 (0.46) | GAATSHRKMT2AL3MBTL1NPSR1 | |
| SCHEMBL9023690 | 0.83 | ALDH1A1 (0.46) | GAATSHRKMT2AL3MBTL1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6034099-A | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones | CELL PATHWAYS, INC. (US) | 2000-03-07 | — | — | US | disclosed |