Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 8/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27430768 | 0.80 | ACHE (0.58) | ACHEADORA2AADORA1MEN1KMT2A | |
| SCHEMBL6618672 | 0.76 | ALDH1A1 (0.55) | ACHEADORA2AADORA1MEN1KMT2A | |
| SCHEMBL3121916 | 0.73 | ADORA1 (0.53) | ACHEADORA2AADORA1MEN1KMT2A | |
| SCHEMBL20125567 | 0.72 | SQOR (0.62) | ADORA2AADORA1MEN1KMT2AALDH1A1 | |
| SCHEMBL13299548 | 0.72 | ALDH1A1 (0.69) | ADORA2AADORA1MEN1KMT2AALDH1A1 | |
| SCHEMBL27489654 | 0.72 | NPC1 (0.50) | ACHEADORA2AADORA1MEN1KMT2A | |
| SCHEMBL6813816 | 0.71 | ADORA2A (0.73) | ADORA2AADORA1MEN1KMT2AALDH1A1 | |
| SCHEMBL2873300 | 0.71 | ACHE (1.00) | ACHEADORA2AADORA1MEN1KMT2A | |
| SCHEMBL8265150 | 0.71 | ADORA2A (0.66) | ACHEADORA2AADORA1MEN1KMT2A | |
| SCHEMBL14927901 | 0.71 | ADORA2A (0.55) | ACHEADORA2AADORA1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6117893-A | Heterocyclic compounds having anti-diabetic activity and their use | SANKYO COMPANY, LIMITED (JP) | 2000-09-12 | — | — | US | disclosed |
| US-5834501-A | TREATING DIABETES OR HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 1998-11-10 | — | — | US | disclosed |
| CN-1118781-A | Heterocyclic compound with activity against diabetes and preparation and application of same | MITSUTAKA CO LTD (JP) | 1996-03-20 | — | — | CN | disclosed |