SCHEMBL801247

SCHEMBL801247

O=C(O)c1cc([N+](=O)[O-])cnc1Cl

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.47
CTSV O60911 1/20 0.44
CTSL P07711 1/20 0.44
ALDH1A1 P00352 5/20 0.44
TDP1 Q9NUW8 3/20 0.44
CYP3A4 P08684 1/20 0.44
ALOX15 P16050 1/20 0.44
KMT2A Q03164 3/20 0.43
MAPK1 P28482 1/20 0.43
SMN1; SMN2 Q16637 3/20 0.43
MEN1 O00255 2/20 0.43
HTT P42858 2/20 0.43
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
PLA2G1B P04054 1/20 0.43
ATG4B Q9Y4P1 1/20 0.43
GAA P10253 1/20 0.41
TP53 P04637 1/20 0.41
LMNA P02545 1/20 0.41
MYC P01106 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30036327 1.00 MAPT (0.47) MAPTCTSVCTSLALDH1A1TDP1
Hydrochloric Acid SCHEMBL10560974 0.98 MAPT (0.46) MAPTCTSVCTSLALDH1A1TDP1
Hydrochloric Acid SCHEMBL10560963 0.98 MAPT (0.46) MAPTCTSVCTSLALDH1A1TDP1
SCHEMBL6958431 0.86 SMN1; SMN2 (0.43) MAPTALDH1A1TDP1CYP3A4ALOX15
SCHEMBL801045 0.85 CASP1 (0.54) MAPTALDH1A1CYP3A4KMT2ASMN1; SMN2
SCHEMBL17080674 0.85 CYP1A2 (0.43) MAPTALDH1A1CYP3A4ALOX15KMT2A
SCHEMBL4067681 0.82 LMNA (0.49) MAPTALDH1A1CYP3A4KMT2AMAPK1
SCHEMBL30618280 0.81 OPRK1 (0.50) MAPTALDH1A1KMT2AMAPK1SMN1; SMN2
SCHEMBL2692671 0.81 OPRK1 (0.50) MAPTALDH1A1KMT2AMAPK1SMN1; SMN2
SCHEMBL1818933 0.81 MAPT (0.49) MAPTCTSVCTSLALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 176 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116813537-B Preparation method and application of novel flunixin hapten 深圳市绿诗源生物技术有限公司 2024-09-17 CN claimed
CN-116813537-A Preparation method and application of novel flunixin hapten 深圳市绿诗源生物技术有限公司 2023-09-29 CN claimed
US-20260078117-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS INC (US) 2026-03-19 US disclosed
EP-4651907-A1 DRUG CONJUGATES AND METHODS OF PREPARING AND USING THE SAME Adcentrx Therapeutics Inc. (US) 2025-11-26 EP disclosed
EP-4563571-A1 PRMT5 INHIBITORS Beijing Earthwise Technology Co., Ltd. (CN) 2025-06-04 EP disclosed
EP-4536356-A1 PYRIDINAMINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS Xenon Pharmaceuticals Inc. (CA) 2025-04-16 EP disclosed
US-12264154-B2 Compounds and methods of use TANGO THERAPEUTICS, INC. (US) 2025-04-01 US disclosed
CN-119731154-A PRMT5 inhibitors 北京望实智慧科技有限公司 2025-03-28 CN disclosed
CN-116813537-B Preparation method and application of novel flunixin hapten 深圳市绿诗源生物技术有限公司 2024-09-17 CN disclosed
WO-2024155761-A1 DRUG CONJUGATES AND METHODS OF PREPARING AND USING THE SAME ADCENTRX THERAPEUTICS INC. (US) 2024-07-25 WO disclosed
US-20240228478-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS, INC. 2024-07-11 US disclosed
US-5705499-A VIRICIDES BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 1998-01-06 US disclosed
US-5620974-A ENZYME INHIBITOR, TREATS ACQUIRED IMMUNE DEFICIENCY SYNDROME(AIDS) BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 1997-04-15 US disclosed
EP-0767172-A1 8-Arylalkyl- and 8-arylheteroalkyl-5, 11-dihydro-6H-dipyrido-[3,2-b:2', 3'-e][1,4]diazepines and their use in the prevention or treatment of HIV infection BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) 1997-04-09 EP disclosed
US-5550122-A INHIBIT REVERSE TRANSCRIPTASE BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 1996-08-27 US disclosed
EP-0415303-B1 Pyrido [2,3-b][1,5]benzoxazepin (and thiazepin)-5(6H)-ones and -thiones and their use in the prevention or treatment of HIV infection BOEHRINGER INGELHEIM PHARMA (US) 1995-12-13 EP disclosed
EP-0634413-A1 Herbicides RHONE POULENC AGRICULTURE LTD. (GB) 1995-01-18 EP disclosed
US-5366972-A 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 1994-11-22 US disclosed
EP-0429987-A2 5,11-Dihydro-6H-dipyrido[3,2-b:2',3'-e] [1,4]diazepines and their use in the prevention or treatment of HIV infection BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) 1991-06-05 EP disclosed
EP-0415303-A2 Pyrido [2,3-b][1,5]benzoxazepin (and thiazepin)-5(6H)-ones and -thiones and their use in the prevention or treatment of HIV infection BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) 1991-03-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12264154-B2 Compounds and methods of use F12, C1R, ABCG2 MAPT 2749/4885CTSV 1063/4885CTSL 1362/4885
US-20240228478-A1 COMPOUNDS AND METHODS OF USE F12, C1R, ABCG2 MAPT 2749/4885CTSV 1063/4885CTSL 1362/4885
US-20260078117-A1 COMPOUNDS AND METHODS OF USE NR3C2, ADRA1A, CNR1 MAPT 4259/4885CTSV 1913/4885CTSL 2421/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.