Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 13/20 | 1.00 |
| ▸ | BACE1 | P56817 | 2/20 | 1.00 |
| ▸ | BCHE | P06276 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29506653 | 1.00 | ACHE (1.00) | ACHEBACE1BCHE | |
| SCHEMBL1877163 | 1.00 | ACHE (1.00) | ACHEBACE1BCHE | |
| SCHEMBL3086109 | 1.00 | ACHE (1.00) | ACHEBACE1BCHE | |
| SCHEMBL29506655 | 1.00 | ACHE (1.00) | ACHEBACE1BCHE | |
| Hydrochloric Acid SCHEMBL4205699 | 0.99 | ACHE (0.98) | ACHEBACE1BCHE | |
| Hydrochloric Acid SCHEMBL29506654 | 0.99 | ACHE (0.98) | ACHEBACE1BCHE | |
| SCHEMBL24401463 | 0.94 | ACHE (0.89) | ACHEBACE1BCHE | |
| SCHEMBL14601859 | 0.94 | ACHE (0.89) | ACHEBACE1BCHE | |
| SCHEMBL4200014 | 0.93 | ACHE (0.87) | ACHEBACE1BCHE | |
| SCHEMBL6857051 | 0.93 | ACHE (0.87) | ACHEBACE1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112641773-A | Composition containing heterocyclic compound and use thereof | 黄泳华 | 2021-04-13 | — | — | CN | claimed |
| CN-111265524-A | Compositions containing mixtures of indene or indane derivatives and uses thereof | 黄泳华 | 2020-06-12 | — | — | CN | claimed |
| CN-112641773-A | Composition containing heterocyclic compound and use thereof | 黄泳华 | 2021-04-13 | — | — | CN | disclosed |
| CN-111265524-A | Compositions containing mixtures of indene or indane derivatives and uses thereof | 黄泳华 | 2020-06-12 | — | — | CN | disclosed |
| US-9249098-B2 | Derivatives of donepezil | CHENG XUEHENG (US) | 2016-02-02 | — | — | US | disclosed |
| US-9249098-B2 | Derivatives of donepezil | CHENG XUEHENG (US) | 2016-02-02 | — | — | US | disclosed |
| US-20150225343-A1 | NOVEL DERIVATIVES OF DONEPEZIL | CHENG XUEHENG (US) | 2015-08-13 | — | — | US | disclosed |
| US-20150225343-A1 | NOVEL DERIVATIVES OF DONEPEZIL | CHENG XUEHENG (US) | 2015-08-13 | — | — | US | disclosed |
| WO-2014008629-A1 | NOVEL DERIVATIVES OF DONEPEZIL | SUZHOU SHANGZHI BIOTECH LIMITED (CN) | 2014-01-16 | — | — | WO | disclosed |
| WO-2012170599-A1 | NEUROGENESIS BY MUSCARINIC RECEPTOR MODULATION | BRAINCELLS, INC. (US) | 2012-12-13 | — | — | WO | disclosed |
| US-20110319386-A1 | NEUROGENESIS BY MUSCARINIC RECEPTOR MODULATION | BRAINCELLS INC. (US) | 2011-12-29 | — | — | US | disclosed |
| US-20100143505-A1 | INDANONE INHIBITORS OF ACETYLCHOLINESTERASE | AUSPEX PHARMACEUTICALS, INC. (US) | 2010-06-10 | — | — | US | disclosed |
| US-20100113793-A1 | Process for the Preparation of Highly Pure Donepezil | IND-SWIFT LABORATORIES LIMITED (IN) | 2010-05-06 | — | — | US | disclosed |
| US-20100113793-A1 | Process for the Preparation of Highly Pure Donepezil | IND-SWIFT LABORATORIES LIMITED (IN) | 2010-05-06 | — | — | US | disclosed |
| WO-2009084030-A2 | IMPROVED PROCESS FOR THE PREPARATION OF (1-BENZYL-4-(5,6,- DIMETHOXYIND ANONE-2-YL)METHYLPIPERIDINE) HYDROCHLORIDE-FORM III | NEULAND LABORATORIES LTD. (IN) | 2009-07-09 | — | — | WO | disclosed |
| WO-2008126995-A1 | A PROCESS FOR PREPARING INTERMEDIATE OF DONEPEZIL | DONG WHA PHARM. IND. CO., LTD. (KR) | 2008-10-23 | — | — | WO | disclosed |
| EP-1911745-A1 | PROCESS FOR PRODUCING 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANONE)-2-YLIDENE]METHYLPIPERIDINE | Eisai R&D Management Co., Ltd. (JP) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007108011-A2 | PROCESS FOR THE PREPARATION OF HIGHLY PURE DONEPEZIL | IND-SWIFT LABORATORIES LIMITED (IN) | 2007-09-27 | — | — | WO | disclosed |
| US-20070135644-A1 | PROCESS FOR MAKING DONEPEZIL | SYNTHON BV (NL) | 2007-06-14 | — | — | US | disclosed |
| US-20070135644-A1 | PROCESS FOR MAKING DONEPEZIL | SYNTHON BV (NL) | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319386-A1 | NEUROGENESIS BY MUSCARINIC RECEPTOR MODULATION | CHRNB2, CHAT, CHRNB4 | ACHE 18/4885BACE1 233/4885BCHE 42/4885 |
| US-20100113793-A1 | Process for the Preparation of Highly Pure Donepezil | PSEN1, ACHE, PSEN2 | ACHE 2/4885BACE1 17/4885BCHE 5/4885 |
| US-20100143505-A1 | INDANONE INHIBITORS OF ACETYLCHOLINESTERASE | ACHE, BCHE, CHAT | ACHE 1/4885BACE1 11/4885BCHE 2/4885 |
| US-20150225343-A1 | NOVEL DERIVATIVES OF DONEPEZIL | ACHE, BCHE, HNMT | ACHE 1/4885BACE1 7/4885BCHE 2/4885 |
| US-20070135644-A1 | PROCESS FOR MAKING DONEPEZIL | MAOA, ACHE, CHAT | ACHE 2/4885BACE1 57/4885BCHE 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.