Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | BACE1 | P56817 | 7/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | WNT1 | P04628 | 1/20 | 0.37 |
| ▸ | KDM6B | O15054 | 2/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | CLK3 | P49761 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8019029 | 0.90 | CYP2C19 (0.43) | GRIA2CYP2C19MAOABACE1PRMT5 | |
| SCHEMBL8014207 | 0.83 | MAOA (0.46) | MAOA | |
| SCHEMBL8028625 | 0.79 | GRM5 (0.38) | GRIA2MAOAKCNH2CHRNB2CHRNA6 | |
| SCHEMBL8014184 | 0.79 | DRD2 (0.46) | MAOAPRMT5WDR77DYRK1A | |
| SCHEMBL1010606 | 0.77 | CYP2C19 (0.44) | GRIA2CYP2C19MAOABACE1CYP11B2 | |
| SCHEMBL8023498 | 0.76 | CYP11B1 (0.51) | CYP11B2 | |
| SCHEMBL8014211 | 0.76 | MAOA (0.44) | GRIA2MAOACYP11B2KCNH2CHRNB2 | |
| SCHEMBL8028105 | 0.75 | MAOA (0.49) | MAOACYP11B2KDM6BKDM4C | |
| SCHEMBL8030414 | 0.74 | MAOA (0.46) | MAOA | |
| SCHEMBL8032013 | 0.72 | MAOA (0.56) | MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |