Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 5/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8066867 | 0.86 | PDE4B (0.46) | PDE4BPDE4DHDAC4HDAC2HDAC8 | |
| SCHEMBL8067030 | 0.86 | PDE4D (0.49) | PDE4BPDE4DHDAC4HDAC2HDAC8 | |
| SCHEMBL8067827 | 0.83 | GAA (0.51) | PDE4BPDE4DFFAR1MAPTMEN1 | |
| SCHEMBL8066904 | 0.82 | PDE4D (0.54) | PDE4BPDE4DHDAC4HDAC2HDAC8 | |
| SCHEMBL8071940 | 0.82 | PDE4D (0.51) | PDE4BPDE4DHDAC4HDAC2HDAC8 | |
| SCHEMBL8066338 | 0.81 | PDE4D (0.53) | PDE4BPDE4DHDAC4HDAC2HDAC8 | |
| SCHEMBL8028169 | 0.80 | PDE4D (0.49) | PDE4BPDE4DHDAC4HDAC2HDAC8 | |
| SCHEMBL8065375 | 0.80 | PDE4D (0.47) | PDE4BPDE4DHDAC4HDAC2HDAC8 | |
| SCHEMBL8065317 | 0.80 | PDE4D (0.47) | PDE4BPDE4DHDAC4HDAC2HDAC8 | |
| SCHEMBL15906086 | 0.80 | SMN1; SMN2 (0.45) | PDE4BPDE4DHTR7ALOX5GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2628727-A2 | Biaryl PDE4 inhibitors for treating pulmonary and cardiovascular disorders | Decode Genetics EHF (IS) | 2013-08-21 | — | — | EP | disclosed |
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |
| WO-2009067621-A1 | BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |