Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Triclosan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 6/20 | 0.96 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.96 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.96 |
| ▸ | HPGD | P15428 | 2/20 | 0.96 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.96 |
| ▸ | LMNA | P02545 | 1/20 | 0.96 |
| ▸ | PGR | P06401 | 1/20 | 0.96 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.96 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.96 |
| ▸ | MAPT | P10636 | 1/20 | 0.96 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.96 |
| ▸ | CBR1 | P16152 | 1/20 | 0.96 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.96 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.96 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triclosan SCHEMBL5316191 | 0.98 | TTR (0.92) | TTRSLC6A2SLC6A3HPGDNR1I2 | |
| Triclosan SCHEMBL3269 | 0.98 | TTR (1.00) | TTRSLC6A2SLC6A3HPGDNR1I2 | |
| Triclosan SCHEMBL29354475 | 0.98 | TTR (1.00) | TTRSLC6A2SLC6A3HPGDNR1I2 | |
| Triclosan SCHEMBL29356111 | 0.98 | TTR (1.00) | TTRSLC6A2SLC6A3HPGDNR1I2 | |
| Triclosan SCHEMBL29367506 | 0.98 | TTR (1.00) | TTRSLC6A2SLC6A3HPGDNR1I2 | |
| Triclosan SCHEMBL526378 | 0.98 | TTR (1.00) | TTRSLC6A2SLC6A3HPGDNR1I2 | |
| Triclosan SCHEMBL3895700 | 0.96 | TTR (0.96) | TTRSLC6A2SLC6A3HPGDNR1I2 | |
| Triclosan SCHEMBL434693 | 0.96 | TTR (0.96) | TTRSLC6A2SLC6A3HPGDNR1I2 | |
| Triclosan SCHEMBL1146628 | 0.96 | TTR (0.96) | TTRSLC6A2SLC6A3HPGDNR1I2 | |
| Triclosan SCHEMBL8055151 | 0.96 | TTR (0.96) | TTRSLC6A2SLC6A3HPGDNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1024778-A1 | PROTECTIVE VARNISH FOR DENTIN | DENTSPLY INTERNATIONAL, INC. (US) | 2000-08-09 | — | — | EP | disclosed |
| EP-0980234-A1 | ANTIMICROBIAL DENTAL MATERIALS CONTAINING 2,4,4'-TRICHLORO-2'-HYDROXYDIPHENYL ETHER | DENTSPLY INTERNATIONAL, INC. (US) | 2000-02-23 | — | — | EP | disclosed |
| WO-1999020227-A1 | PROTECTIVE VARNISH FOR DENTIN | DENTSPLY INTERNATIONAL INC. (US) | 1999-04-29 | — | — | WO | disclosed |
| WO-1998048766-A1 | ANTIMICROBIAL DENTAL MATERIALS CONTAINING 2,4,4'-TRICHLORO-2'-HYDROXYDIPHENYL ETHER | DENTSPLY INTERNATIONAL INC. (US) | 1998-11-05 | — | — | WO | disclosed |