Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Triclosan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 6/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | PGR | P06401 | 1/20 | 1.00 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | HSPA5 | P11021 | 1/20 | 1.00 |
| ▸ | CBR1 | P16152 | 1/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 1/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 1/20 | 1.00 |
| ▸ | AGTR1 | P30556 | 1/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triclosan SCHEMBL3269 | 1.00 | TTR (1.00) | TTRHPGDNR1I2LMNAPGR | |
| Triclosan SCHEMBL526378 | 1.00 | TTR (1.00) | TTRHPGDNR1I2LMNAPGR | |
| Triclosan SCHEMBL29354475 | 1.00 | TTR (1.00) | TTRHPGDNR1I2LMNAPGR | |
| Triclosan SCHEMBL29367506 | 1.00 | TTR (1.00) | TTRHPGDNR1I2LMNAPGR | |
| Triclosan SCHEMBL8015104 | 0.98 | TTR (0.96) | TTRHPGDNR1I2LMNAPGR | |
| Triclosan SCHEMBL8975439 | 0.98 | TTR (0.96) | TTRHPGDNR1I2LMNAPGR | |
| Triclosan SCHEMBL1146628 | 0.98 | TTR (0.96) | TTRHPGDNR1I2LMNAPGR | |
| Triclosan SCHEMBL3895700 | 0.98 | TTR (0.96) | TTRHPGDNR1I2LMNAPGR | |
| Triclosan SCHEMBL8055151 | 0.98 | TTR (0.96) | TTRHPGDNR1I2LMNAPGR | |
| Triclosan SCHEMBL434693 | 0.98 | TTR (0.96) | TTRHPGDNR1I2LMNAPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 214 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4565196-A1 | A PRESERVATIVE COMPOSITION | AnalytiCon Discovery - Zweigniederlassung der BRAIN Biotech AG (DE) | 2025-06-11 | — | — | EP | claimed |
| EP-3836851-B1 | ABRADABLE THERAPEUTIC COATINGS AND DEVICES INCLUDING SUCH COATINGS | ETHICON INC (US) | 2024-06-05 | — | — | EP | claimed |
| WO-2024028266-A1 | A PRESERVATIVE COMPOSITION | BRAIN Biotech AG (DE) | 2024-02-08 | — | — | WO | claimed |
| US-12616948-B2 | Polyamide microcapsules | FIRMENICH SA (CH) | 2026-05-05 | — | — | US | disclosed |
| WO-2026087780-A1 | CORE-SHELL MICROCAPSULES | FIRMENICH SA (CH) | 2026-04-30 | — | — | WO | disclosed |
| WO-2026087745-A1 | AN ANTIOXIDANT COMPOSITION COMPRISING A CINNAMIC ACID DERIVATIVE | BRAIN Biotech AG (DE) | 2026-04-30 | — | — | WO | disclosed |
| US-12582753-B2 | Systems and methods for forming an antimicrobial orthopedic implant | DePuy Synthes Products, Inc. (US) | 2026-03-24 | — | — | US | disclosed |
| EP-4711037-A2 | PERFUME FORMULATION FOR DELIVERY SYSTEM | Firmenich SA (CH) | 2026-03-18 | — | — | EP | disclosed |
| EP-4711438-A2 | PERFUME DELIVERY SYSTEM | Firmenich SA (CH) | 2026-03-18 | — | — | EP | disclosed |
| EP-4705765-A2 | BUCCAL CELL DIAGNOSIS OF RISK IN FAMILIAL ARRHYTHMIA SYNDROMES | Beth Israel Deaconess Medical Center, Inc. (US) | 2026-03-11 | — | — | EP | disclosed |
| US-12551247-B1 | Bone anchors and surgical instruments with integrated guide tips | DePuy Synthes Products, Inc. (US) | 2026-02-17 | — | — | US | disclosed |
| US-11311318-B2 | Bone anchor assemblies and methods with improved locking | DePuy Synthes Products, Inc. (US) | 2022-04-26 | — | — | US | disclosed |
| WO-2022079142-A1 | LIQUID COMPOSITION FOR USE IN THE PREVENTION OR REDUCTION OF SKIN IRRITATION, ALLERGY AND/OR AN INFECTIOUS DISEASE | MEDODERM GMBH (DE) | 2022-04-21 | — | — | WO | disclosed |
| EP-3982910-A1 | A COOLING PREPARATION | Symrise AG (DE) | 2022-04-20 | — | — | EP | disclosed |
| US-11298158-B2 | Connectors for use in systems and methods for reducing the risk of proximal junctional kyphosis | MEDOS INTERNATIONAL SARL (CH) | 2022-04-12 | — | — | US | disclosed |
| US-20220071666-A1 | BONE ANCHORS | MEDOS INTERNATIONAL SARL (CH) | 2022-03-10 | — | — | US | disclosed |
| US-20220055006-A1 | PROCESS FOR PREPARING POLYAMIDE MICROCAPSULES | FIRMENICH SA (CH) | 2022-02-24 | — | — | US | disclosed |
| US-20220039835-A1 | OFFSET RODS, OFFSET ROD CONNECTORS, AND RELATED METHODS | MEDOS INT SARL (CH) | 2022-02-10 | — | — | US | disclosed |
| US-20220039797-A1 | ADJUNCT MATERIALS AND METHODS OF USING SAME IN SURGICAL METHODS FOR TISSUE SEALING | CILAG GMBH INTERNATIONAL (CH) | 2022-02-10 | — | — | US | disclosed |
| EP-3626190-B1 | DEVICES FOR SPINAL SCREW INSERTION | DEPUY SYNTHES PRODUCTS INC (US) | 2022-01-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12551247-B1 | Bone anchors and surgical instruments with integrated guide tips | TOE1, BMP2, SYVN1 | TTR 1476/4885HPGD 4837/4885NR1I2 2241/4885 |
| US-12582753-B2 | Systems and methods for forming an antimicrobial orthopedic implant | SPOUT1, CUTA, CAPG | TTR 1684/4885HPGD 3956/4885NR1I2 2776/4885 |
| US-12616948-B2 | Polyamide microcapsules | HDHD5, DDC, USP39 | TTR 85/4885HPGD 3492/4885NR1I2 4511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.