Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Triclosan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 6/20 | 0.96 |
| ▸ | HPGD | P15428 | 2/20 | 0.96 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.96 |
| ▸ | LMNA | P02545 | 1/20 | 0.96 |
| ▸ | PGR | P06401 | 1/20 | 0.96 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.96 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.96 |
| ▸ | MAPT | P10636 | 1/20 | 0.96 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.96 |
| ▸ | CBR1 | P16152 | 1/20 | 0.96 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.96 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.96 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.96 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.96 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triclosan SCHEMBL29367506 | 0.98 | TTR (1.00) | TTRHPGDNR1I2LMNAPGR | |
| Triclosan SCHEMBL29356111 | 0.98 | TTR (1.00) | TTRHPGDNR1I2LMNAPGR | |
| Triclosan SCHEMBL526378 | 0.98 | TTR (1.00) | TTRHPGDNR1I2LMNAPGR | |
| Triclosan SCHEMBL29354475 | 0.98 | TTR (1.00) | TTRHPGDNR1I2LMNAPGR | |
| Triclosan SCHEMBL3269 | 0.98 | TTR (1.00) | TTRHPGDNR1I2LMNAPGR | |
| Triclosan SCHEMBL8015104 | 0.96 | TTR (0.96) | TTRHPGDNR1I2LMNAPGR | |
| Triclosan SCHEMBL8975439 | 0.96 | TTR (0.96) | TTRHPGDNR1I2LMNAPGR | |
| Triclosan SCHEMBL8055151 | 0.96 | TTR (0.96) | TTRHPGDNR1I2LMNAPGR | |
| Triclosan SCHEMBL3895700 | 0.96 | TTR (0.96) | TTRHPGDNR1I2LMNAPGR | |
| Triclosan SCHEMBL1146628 | 0.96 | TTR (0.96) | TTRHPGDNR1I2LMNAPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9814239-B2 | Antimicrobial complexes | Liu, Huiwen (US) | 2017-11-14 | — | — | US | disclosed |
| US-20160073636-A1 | ANTIMICROBIAL COMPLEXES | LIU HUIWEN (US) | 2016-03-17 | — | — | US | disclosed |
| CN-103179855-B | Antimicrobial complexes | LIU HUIWEN | 2015-07-08 | — | — | CN | disclosed |
| CN-103179855-A | Antimicrobial complexes | LIU HUIWEN | 2013-06-26 | — | — | CN | disclosed |
| WO-2012012049-A2 | ANTIMICROBIAL COMPLEXES | LIU HUIWEN (US) | 2012-01-26 | — | — | WO | disclosed |
| EP-2209763-A2 | A PROCESS FOR THE PREPARATION OF 5-CHLORO-2(2,4-DICHLOROPHENOXY) ANILINE | Dorf Ketal Chemicals (I) Private Limited (IN) | 2010-07-28 | — | — | EP | disclosed |
| WO-2009090669-A2 | A PROCESS FOR THE PREPARATION OF 5-CHLORO-2(2,4-DICHLOROPHENOXY) ANILINE | DORF KETAL CHEMICALS (I) PRIVATE LIMITED (IN) | 2009-07-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160073636-A1 | ANTIMICROBIAL COMPLEXES | ZC3HAV1, MAVS, ZC3HAV1L | TTR 3609/4885HPGD 3927/4885NR1I2 3696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.