Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | CRHBP | P24387 | 1/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 4/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8018278 | 0.91 | HPGD (0.60) | HPGDALDH1A1KDM4ECRHBPCRHR2 | |
| SCHEMBL8019463 | 0.88 | HPGD (0.53) | HPGDALDH1A1KDM4ECRHBPCRHR2 | |
| SCHEMBL8015840 | 0.87 | TP53 (0.67) | HPGDALDH1A1KDM4ERXFP1NPSR1 | |
| SCHEMBL8019456 | 0.82 | KDM4E (0.64) | HPGDALDH1A1KDM4ECRHBPCRHR2 | |
| SCHEMBL8019460 | 0.82 | HTR6 (0.60) | HPGDALDH1A1KDM4EGAARXFP1 | |
| SCHEMBL8028247 | 0.81 | HTR6 (0.48) | RXFP1MAPTPOLBHTR6 | |
| SCHEMBL8029045 | 0.79 | KDM4E (0.61) | HPGDALDH1A1KDM4ECRHBPCRHR2 | |
| SCHEMBL8019490 | 0.78 | HTR6 (0.72) | HPGDALDH1A1KDM4ERXFP1NPSR1 | |
| SCHEMBL10123316 | 0.76 | THRB (0.63) | HPGDALDH1A1KDM4EGAARXFP1 | |
| SCHEMBL8030043 | 0.75 | HTR6 (0.50) | HPGDALDH1A1KDM4ECRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009093934-A2 | SUBSTITUTED 3-SULPHONYL-[1,2,3]TRIAZOLO [1,5-A]PYRIMIDINES-ANTAGONISTS OF SEROTONIN 5-HT6 RECEPTORS, MEDICINAL SUBSTANCE, PHARMACEUTICAL COMPOSITION, MEDICINAL PREPARATION AND METHODS FOR THE PRODUCTION THEREOF | ALLA CHEM, LLC (US) | 2009-07-30 | — | — | WO | disclosed |