Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | HTR1D | P28221 | 2/20 | 0.54 |
| ▸ | HTR2C | P28335 | 2/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 2/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8690961 | 0.88 | PIM1 (0.53) | HTR1AHTR1DHTR2CALDH1A1TSHR | |
| SCHEMBL8690168 | 0.86 | HTR1A (0.48) | HTR1AHTR1DHTR2CMTNR1BSIRT1 | |
| SCHEMBL7019210 | 0.81 | MTNR1A (0.49) | HTR1AHTR1DHTR2CMTNR1BSIRT1 | |
| SCHEMBL8695023 | 0.80 | MTNR1A (0.65) | HTR2CMTNR1BALDH1A1TSHRNPC1 | |
| SCHEMBL11365468 | 0.80 | MAOB (0.51) | HTR1AHTR1DHTR2CMAOB | |
| SCHEMBL7014521 | 0.78 | HTR1A (0.47) | HTR1AHTR1DHTR2CMTNR1BSIRT1 | |
| SCHEMBL2269511 | 0.78 | MTNR1A (0.51) | HTR1AHTR1DHTR2CMTNR1BSIRT1 | |
| SCHEMBL2267233 | 0.77 | NPC1 (0.49) | SIRT1ALDH1A1TSHRNPSR1MAPT | |
| SCHEMBL24938760 | 0.76 | ALOX15 (0.59) | SIRT1ALDH1A1TSHRNPSR1MAPT | |
| SCHEMBL5340289 | 0.76 | MTNR1A (0.48) | HTR1AHTR1DHTR2CMTNR1BSIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745584-B1 | Arylalkyl(thio) carboxamides compounds with affinity for melatonine receptors, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-01-05 | — | — | EP | disclosed |
| US-5721276-A | TREATING DISORDERS OF MELATONINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1998-02-24 | — | — | US | disclosed |
| EP-0745584-A1 | Arylalkyl(thio) carboxamides compounds with affinity for melatonine receptors, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-12-04 | — | — | EP | disclosed |