Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705631 | 0.79 | ADRB2 (0.38) | ERCC5FEN1ADRB2ADRB1ADRB3 | |
| SCHEMBL1712501 | 0.78 | NPC1 (0.45) | CES1ALDH1A1RAB9AKMT2AMEN1 | |
| SCHEMBL15066187 | 0.77 | KCNJ5 (0.40) | RAB9ANPC1 | |
| SCHEMBL27208789 | 0.75 | ERCC5 (0.53) | ERCC5FEN1CES2CES1ALDH1A1 | |
| SCHEMBL12497809 | 0.75 | ALDH1A1 (0.51) | ALDH1A1KDM4EMAPT | |
| SCHEMBL6314039 | 0.74 | ERCC5 (0.47) | ERCC5FEN1ALDH1A1RAB9AKMT2A | |
| SCHEMBL15229021 | 0.72 | SMN1; SMN2 (0.41) | ALDH1A1KMT2AMEN1KDM4EMAPT | |
| SCHEMBL4637854 | 0.72 | LMNA (0.53) | ERCC5FEN1CES2CES1ALDH1A1 | |
| SCHEMBL12221571 | 0.72 | ERCC5 (0.53) | ERCC5FEN1ADRB2ADRB1ADRB3 | |
| SCHEMBL12497692 | 0.71 | KCNQ3 (0.39) | ALDH1A1RAB9AKDM4EMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675133-B1 | 13-Substituted milbemycin derivatives, their preparation and use | SANKYO CO (JP) | 2000-01-12 | — | — | EP | disclosed |
| US-5614470-A | AGRICULTURAL ANTHELMINTIC, ACARICIDE, INSECTICIDE | SANKYO COMPANY, LIMITED (JP) | 1997-03-25 | — | — | US | disclosed |
| EP-0675133-A1 | 13-Substituted milbemycin derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1995-10-04 | — | — | EP | disclosed |