Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.44 |
| ▸ | CES1 | P23141 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1518530 | 0.77 | PTGS2 (0.44) | SMN1; SMN2MAPTLMNAALDH1A1HPGD | |
| SCHEMBL4578842 | 0.75 | LMNA (0.41) | CES2CES1SMN1; SMN2MAPTLMNA | |
| SCHEMBL28158669 | 0.74 | SMN1; SMN2 (0.43) | CES2CES1SMN1; SMN2NPSR1MAPT | |
| SCHEMBL3244408 | 0.74 | NPSR1 (0.43) | CES2CES1SMN1; SMN2NPSR1MAPT | |
| SCHEMBL7370238 | 0.74 | SMN1; SMN2 (0.43) | CES2CES1SMN1; SMN2NPSR1MAPT | |
| SCHEMBL13651331 | 0.74 | ESR1 (0.45) | CES2CES1SMN1; SMN2NPSR1MAPT | |
| SCHEMBL6535707 | 0.74 | ESR1 (0.45) | CES2CES1SMN1; SMN2NPSR1MAPT | |
| SCHEMBL28287732 | 0.74 | GAA (0.42) | CES2CES1SMN1; SMN2NPSR1MAPT | |
| SCHEMBL19624236 | 0.74 | ESR1 (0.45) | CES2CES1SMN1; SMN2NPSR1MAPT | |
| SCHEMBL5013786 | 0.74 | TDP1 (0.54) | CES2CES1LMNAATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016087593-A1 | NOVEL FUNGICIDAL QUINOLINYLAMIDINES | SYNGENTA PARTICIPATIONS AG (CH) | 2016-06-09 | — | — | WO | disclosed |
| US-6103732-A | ENDOTHELIN RECEPTOR INHIBITORS; HYPOTENSIVE AGENTS, CARDIOTONIC AGENTS; ACUTE MYOCARDIAL INFARCT, PULMONARY HYPERTENSION, RAYNAUD'S SYNDROME, ATHEROSCLEROSIS; ASTHMA; CARDIOVASCULAR DISORDERS | BASF AKTIENGESELLSCHAFT (DE) | 2000-08-15 | — | — | US | disclosed |
| US-6051569-A | 1'S, 5R, 6R-carbapenem derivatives and antimicrobial agents comprising the same | SUNTORY LIMITED (JP) | 2000-04-18 | — | — | US | disclosed |
| EP-0826687-A1 | Carbapenem derivatives and antimicrobial agents comprising the same | SUNTORY LIMITED (JP) | 1998-03-04 | — | — | EP | disclosed |
| EP-0414200-B1 | Salts of optically active 4-hydroxy-8-(3-lower alkoxy-4-phenylsulfinylphenyl)pyrazolo [1,5-a]-1,3,5-triazines and a process for production thereof | OTSUKA PHARMA CO LTD (JP) | 1995-08-02 | — | — | EP | disclosed |
| CN-1028528-C | Salts of optically active 4-hydroxy-8-(3-lower alkoxy-4-phenylsulfinylphenyl) pyrazolo [1,5-a]-1,3,5-triazines | OTSUKA PHARMA CO LTD (JP) | 1995-05-24 | — | — | CN | disclosed |
| EP-0572547-A1 | SUBSTITUTED $g(a)-AMINOALDEHYDES AND DERIVATIVES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-12-08 | — | — | EP | disclosed |
| US-5180799-A | Organolithium-Organoaluminum Catalyst | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-01-19 | — | — | US | disclosed |
| US-5137887-A | Xanthine oxidase inhibitors, antipodagric agents | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1992-08-11 | — | — | US | disclosed |
| EP-0434316-A1 | Processes | ZENECA LIMITED (GB) | 1991-06-26 | — | — | EP | disclosed |
| CN-1049664-A | Optically active 4-hydroxyl-8-(3-low-alkoxy-4-phenyl sulfinyl phenyl) pyrazolo [1,5-α]-1,3,5-triazines salt and method for making thereof | OTSUKA PHARMA CO LTD (JP) | 1991-03-06 | — | — | CN | disclosed |
| EP-0414200-A2 | Salts of optically active 4-hydroxy-8-(3-lower alkoxy-4-phenylsulfinylphenyl)pyrazolo [1,5-a]-1,3,5-triazines and a process for production thereof | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1991-02-27 | — | — | EP | disclosed |
| US-4963582-A | ANTHELMINTICS, ACARICIDES, INSECTICIDES | SANKYO COMPANY LIMITED (JP) | 1990-10-16 | — | — | US | disclosed |