Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | CTSE | P14091 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7483916 | 0.88 | GPR119 (0.47) | GPR119BCHEKDM4EPKMCTSD | |
| SCHEMBL2606281 | 0.80 | KCNH2 (0.58) | GPR119 | |
| SCHEMBL7479526 | 0.79 | — | — | |
| SCHEMBL6247351 | 0.78 | OXTR (0.53) | GPR119NAMPTPRMT5WDR77KDM4E | |
| SCHEMBL7351827 | 0.77 | OXTR (0.58) | — | |
| SCHEMBL8025466 | 0.76 | OPRM1 (0.46) | HSD17B3 | |
| SCHEMBL499529 | 0.75 | USP30 (0.49) | GPR119BCHEKDM4EPKMSTS | |
| SCHEMBL2707784 | 0.75 | GPR119 (0.52) | GPR119NAMPTPRMT5WDR77KDM4E | |
| SCHEMBL8863377 | 0.74 | OXTR (0.50) | GPR119NAMPTCTSDCTSEBACE1 | |
| SCHEMBL8020392 | 0.74 | ALDH1A1 (0.42) | HSD17B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6063779-A | CARDIOVASCULAR DISORDERS | MEIJI SEIKA KAISHA, LTD. (JP) | 2000-05-16 | — | — | US | disclosed |
| EP-0878475-A2 | 5-(4-Piperidinyl)dibenzothiazepine derivatives and 5-(4-piperidinyl)dibenzoxazepine derivatives, and antiarrhythmic agents | Meiji Seika Kaisha, Ltd. (JP) | 1998-11-18 | — | — | EP | disclosed |