Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8018527 | 1.00 | OPRM1 (0.52) | OPRM1OPRK1MCHR1HTR2AHTR2B | |
| SCHEMBL8025512 | 0.80 | OPRL1 (0.60) | OPRM1OPRK1HTR2AHTR2BSIGMAR1 | |
| SCHEMBL8019105 | 0.79 | OPRM1 (0.53) | OPRM1OPRK1MCHR1HTR2AHTR2B | |
| SCHEMBL8019108 | 0.79 | OPRM1 (0.53) | OPRM1OPRK1MCHR1HTR2AHTR2B | |
| SCHEMBL8021229 | 0.76 | KMT2A (0.41) | OPRM1OPRK1LMNACYP3A4ALDH1A1 | |
| SCHEMBL8020392 | 0.75 | ALDH1A1 (0.42) | OPRM1OPRK1HTR2AHTR2BHTR2C | |
| SCHEMBL8025530 | 0.74 | OPRM1 (0.50) | OPRM1OPRK1HTR2AHTR2BSIGMAR1 | |
| SCHEMBL8008100 | 0.74 | DRD4 (0.45) | OPRM1OPRK1SIGMAR1ALDH1A1CHRM2 | |
| SCHEMBL8025463 | 0.74 | OPRM1 (0.50) | OPRM1OPRK1SIGMAR1DRD2DRD3 | |
| SCHEMBL8018967 | 0.74 | KCNH2 (0.45) | OPRM1OPRK1HTR2AHTR2BSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6063779-A | CARDIOVASCULAR DISORDERS | MEIJI SEIKA KAISHA, LTD. (JP) | 2000-05-16 | — | — | US | disclosed |
| EP-0878475-A2 | 5-(4-Piperidinyl)dibenzothiazepine derivatives and 5-(4-piperidinyl)dibenzoxazepine derivatives, and antiarrhythmic agents | Meiji Seika Kaisha, Ltd. (JP) | 1998-11-18 | — | — | EP | disclosed |