Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.50 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | OXTR | P30559 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8025512 | 0.91 | OPRL1 (0.60) | OPRM1OPRK1OPRL1SIGMAR1DRD2 | |
| SCHEMBL8025530 | 0.86 | OPRM1 (0.50) | OPRM1OPRK1OPRL1SIGMAR1DRD2 | |
| SCHEMBL8008100 | 0.82 | DRD4 (0.45) | OPRM1OPRK1OPRL1PARP1SIGMAR1 | |
| SCHEMBL8020392 | 0.76 | ALDH1A1 (0.42) | OPRM1OPRK1OPRL1DRD2DRD4 | |
| SCHEMBL8018967 | 0.75 | KCNH2 (0.45) | OPRM1OPRK1OPRL1SIGMAR1DRD2 | |
| SCHEMBL8022964 | 0.75 | OPRM1 (0.42) | OPRM1OPRK1OPRL1SIGMAR1DRD2 | |
| SCHEMBL8018527 | 0.74 | OPRM1 (0.52) | OPRM1OPRK1OPRL1SIGMAR1DRD2 | |
| SCHEMBL8018530 | 0.74 | OPRM1 (0.52) | OPRM1OPRK1OPRL1SIGMAR1DRD2 | |
| SCHEMBL8021216 | 0.73 | DRD2 (0.41) | OPRM1OPRK1OPRL1DRD2DRD4 | |
| SCHEMBL8008566 | 0.73 | OPRM1 (0.46) | OPRM1OPRK1OPRL1SIGMAR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6063779-A | CARDIOVASCULAR DISORDERS | MEIJI SEIKA KAISHA, LTD. (JP) | 2000-05-16 | — | — | US | disclosed |
| EP-0878475-A2 | 5-(4-Piperidinyl)dibenzothiazepine derivatives and 5-(4-piperidinyl)dibenzoxazepine derivatives, and antiarrhythmic agents | Meiji Seika Kaisha, Ltd. (JP) | 1998-11-18 | — | — | EP | disclosed |