Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 2/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 6/20 | 0.48 |
| ▸ | DRD4 | P21917 | 6/20 | 0.48 |
| ▸ | DRD3 | P35462 | 6/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8025530 | 0.91 | OPRM1 (0.50) | OPRL1OPRM1OPRK1SIGMAR1DRD2 | |
| SCHEMBL8025463 | 0.91 | OPRM1 (0.50) | OPRL1OPRM1OPRK1SIGMAR1DRD2 | |
| SCHEMBL8008100 | 0.83 | DRD4 (0.45) | OPRL1OPRM1OPRK1SIGMAR1DRD2 | |
| SCHEMBL8022964 | 0.83 | OPRM1 (0.42) | OPRL1OPRM1OPRK1SIGMAR1DRD2 | |
| SCHEMBL8018527 | 0.80 | OPRM1 (0.52) | OPRL1OPRM1OPRK1SIGMAR1DRD2 | |
| SCHEMBL8018530 | 0.80 | OPRM1 (0.52) | OPRL1OPRM1OPRK1SIGMAR1DRD2 | |
| SCHEMBL8020392 | 0.80 | ALDH1A1 (0.42) | OPRL1OPRM1OPRK1DRD2DRD4 | |
| SCHEMBL8018967 | 0.79 | KCNH2 (0.45) | OPRL1OPRM1OPRK1SIGMAR1DRD2 | |
| SCHEMBL8022963 | 0.78 | OPRM1 (0.40) | OPRL1OPRM1OPRK1DRD2DRD4 | |
| SCHEMBL8021216 | 0.77 | DRD2 (0.41) | OPRL1OPRM1OPRK1DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6063779-A | CARDIOVASCULAR DISORDERS | MEIJI SEIKA KAISHA, LTD. (JP) | 2000-05-16 | — | — | US | disclosed |
| EP-0878475-A2 | 5-(4-Piperidinyl)dibenzothiazepine derivatives and 5-(4-piperidinyl)dibenzoxazepine derivatives, and antiarrhythmic agents | Meiji Seika Kaisha, Ltd. (JP) | 1998-11-18 | — | — | EP | disclosed |