Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CES2 | O00748 | 2/20 | 0.47 |
| ▸ | CES1 | P23141 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8018552 | 1.00 | ALDH1A1 (0.50) | ALDH1A1CES2CES1SMN1; SMN2L3MBTL1 | |
| SCHEMBL27208792 | 0.84 | AKR1B1 (0.39) | ALDH1A1SMN1; SMN2L3MBTL1HPGDRAB9A | |
| SCHEMBL6581523 | 0.81 | LMNA (0.52) | ALDH1A1SMN1; SMN2HPGDNPC1GAA | |
| SCHEMBL8018305 | 0.81 | LMNA (0.52) | ALDH1A1SMN1; SMN2HPGDNPC1GAA | |
| SCHEMBL9022614 | 0.81 | MAPT (0.40) | ALDH1A1SMN1; SMN2HPGDGAAPOLB | |
| SCHEMBL28365483 | 0.81 | RAB9A (0.47) | ALDH1A1SMN1; SMN2HPGDRAB9ANPC1 | |
| SCHEMBL3691371 | 0.81 | RAB9A (0.47) | ALDH1A1SMN1; SMN2HPGDRAB9ANPC1 | |
| SCHEMBL3688001 | 0.81 | RAB9A (0.47) | ALDH1A1SMN1; SMN2HPGDRAB9ANPC1 | |
| SCHEMBL6581520 | 0.81 | LMNA (0.52) | ALDH1A1SMN1; SMN2HPGDNPC1GAA | |
| SCHEMBL29883665 | 0.81 | RAB9A (0.47) | ALDH1A1SMN1; SMN2HPGDRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1058011-C | 13-substituted milbemycin derivatives, their preparation and use | SANKYO CO (JP) | 2000-11-01 | — | — | CN | disclosed |
| EP-0675133-B1 | 13-Substituted milbemycin derivatives, their preparation and use | SANKYO CO (JP) | 2000-01-12 | — | — | EP | disclosed |
| US-5614470-A | AGRICULTURAL ANTHELMINTIC, ACARICIDE, INSECTICIDE | SANKYO COMPANY, LIMITED (JP) | 1997-03-25 | — | — | US | disclosed |
| CN-1112119-A | 13-substituted milbemycin derivatives, their preparation and use | SANKYO CO (JP) | 1995-11-22 | — | — | CN | disclosed |
| EP-0675133-A1 | 13-Substituted milbemycin derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1995-10-04 | — | — | EP | disclosed |