Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 6/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | HTR6 | P50406 | 6/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8019456 | 0.86 | KDM4E (0.64) | HPGDALDH1A1GAAKMT2AMAPT | |
| SCHEMBL8033985 | 0.85 | MAPT (0.68) | MAPTRXFP1POLBTP53THRB | |
| SCHEMBL8030786 | 0.83 | RXFP1 (0.65) | HPGDALDH1A1GAAMAPTRXFP1 | |
| SCHEMBL8021777 | 0.78 | HTR6 (0.56) | MAPTRXFP1HTR6POLBTP53 | |
| SCHEMBL8021789 | 0.77 | KDM4E (0.64) | HPGDALDH1A1GAAKMT2AMAPT | |
| SCHEMBL8021786 | 0.77 | KDM4E (0.72) | HPGDALDH1A1GAAKMT2AMAPT | |
| SCHEMBL8032614 | 0.75 | MAPT (0.87) | HPGDALDH1A1GAAKMT2AMAPT | |
| SCHEMBL8030932 | 0.75 | RXFP1 (0.79) | MAPTRXFP1HTR6POLBTP53 | |
| SCHEMBL8030611 | 0.73 | MAPT (0.85) | HPGDALDH1A1GAAKMT2AMAPT | |
| SCHEMBL15285549 | 0.72 | HTR6 (1.00) | MAPTRXFP1HTR6POLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009093934-A2 | SUBSTITUTED 3-SULPHONYL-[1,2,3]TRIAZOLO [1,5-A]PYRIMIDINES-ANTAGONISTS OF SEROTONIN 5-HT6 RECEPTORS, MEDICINAL SUBSTANCE, PHARMACEUTICAL COMPOSITION, MEDICINAL PREPARATION AND METHODS FOR THE PRODUCTION THEREOF | ALLA CHEM, LLC (US) | 2009-07-30 | — | — | WO | disclosed |