Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.64 |
| ▸ | HPGD | P15428 | 7/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.63 |
| ▸ | GAA | P10253 | 4/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 7/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | HTR6 | P50406 | 4/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | CRHBP | P24387 | 1/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8021786 | 0.91 | KDM4E (0.72) | KDM4EHPGDALDH1A1GAAKMT2A | |
| SCHEMBL8021789 | 0.88 | KDM4E (0.64) | KDM4EHPGDALDH1A1GAAKMT2A | |
| SCHEMBL8019479 | 0.86 | HPGD (0.60) | KDM4EHPGDALDH1A1GAAKMT2A | |
| SCHEMBL8018281 | 0.82 | HPGD (0.53) | KDM4EHPGDALDH1A1GAAKMT2A | |
| SCHEMBL8026556 | 0.82 | KDM4E (0.64) | KDM4EHPGDALDH1A1GAAKMT2A | |
| SCHEMBL8031028 | 0.81 | MAPT (0.71) | KDM4EALDH1A1GAAKMT2ARXFP1 | |
| SCHEMBL8021777 | 0.81 | HTR6 (0.56) | RXFP1MAPTPOLBHTR6TP53 | |
| SCHEMBL8018835 | 0.79 | HPGD (0.69) | KDM4EHPGDALDH1A1GAAKMT2A | |
| SCHEMBL8031022 | 0.79 | HTR6 (0.72) | KDM4EHPGDALDH1A1GAAKMT2A | |
| SCHEMBL8031518 | 0.78 | RXFP1 (0.70) | KDM4EHPGDALDH1A1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009093934-A2 | SUBSTITUTED 3-SULPHONYL-[1,2,3]TRIAZOLO [1,5-A]PYRIMIDINES-ANTAGONISTS OF SEROTONIN 5-HT6 RECEPTORS, MEDICINAL SUBSTANCE, PHARMACEUTICAL COMPOSITION, MEDICINAL PREPARATION AND METHODS FOR THE PRODUCTION THEREOF | ALLA CHEM, LLC (US) | 2009-07-30 | — | — | WO | disclosed |