Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8018788 | 0.88 | MAPT (0.48) | MAPTLMNARAPGEF4ALDH1A1KDM4E | |
| SCHEMBL8015467 | 0.81 | LMNA (0.50) | MAPTLMNAALDH1A1GAAKDM4E | |
| SCHEMBL8017392 | 0.78 | MAPT (0.71) | MAPTLMNARAPGEF4ALDH1A1GAA | |
| SCHEMBL8015787 | 0.76 | LMNA (0.48) | MAPTLMNARAPGEF4ALDH1A1GAA | |
| SCHEMBL8006080 | 0.74 | LMNA (0.57) | MAPTLMNARAPGEF4ALDH1A1MAPK1 | |
| SCHEMBL29196035 | 0.70 | RAPGEF4 (0.71) | MAPTRAPGEF4ALDH1A1GAAKDM4E | |
| SCHEMBL8019313 | 0.70 | MAPT (0.48) | MAPTLMNAALDH1A1GAAKDM4E | |
| SCHEMBL8022779 | 0.69 | MAPT (0.50) | MAPTLMNAALDH1A1GAAKDM4E | |
| SCHEMBL8022790 | 0.69 | LMNA (0.50) | MAPTLMNAALDH1A1GAAKDM4E | |
| SCHEMBL29152731 | 0.68 | NPC1 (0.45) | MAPTLMNAALDH1A1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130228-A | Polycyclic compounds | UNIVERSITY OF STRATHCLYDE (GB) | 2000-10-10 | — | — | US | disclosed |