Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8019313 | 0.81 | MAPT (0.48) | LMNAMAPTSMN1; SMN2TP53RAB9A | |
| SCHEMBL8022779 | 0.81 | MAPT (0.50) | LMNAMAPTRAB9ANPC1MEN1 | |
| SCHEMBL8015787 | 0.75 | LMNA (0.48) | LMNAMAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL8017798 | 0.73 | MAPT (0.71) | LMNAMAPTSMN1; SMN2TP53RAB9A | |
| SCHEMBL8006281 | 0.73 | MAPT (0.60) | LMNAMAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL8019573 | 0.72 | MAPT (0.55) | LMNAMAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL8015744 | 0.70 | MAPT (0.66) | LMNAMAPTRAB9ANPC1MEN1 | |
| SCHEMBL8015461 | 0.70 | LMNA (0.57) | LMNAMAPTRAB9ANPC1ALDH1A1 | |
| SCHEMBL8019487 | 0.69 | MAPT (0.48) | LMNAMAPTSMN1; SMN2TP53RAB9A | |
| SCHEMBL8018788 | 0.69 | MAPT (0.48) | LMNAMAPTSMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130228-A | Polycyclic compounds | UNIVERSITY OF STRATHCLYDE (GB) | 2000-10-10 | — | — | US | disclosed |