Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8015461 | 0.79 | LMNA (0.57) | LMNAMAPTPOLBALDH1A1TDP1 | |
| SCHEMBL8017798 | 0.72 | MAPT (0.71) | LMNAMAPTPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL8017383 | 0.72 | MAPT (0.71) | LMNAMAPTPOLBALDH1A1TDP1 | |
| SCHEMBL8006281 | 0.72 | MAPT (0.60) | LMNAMAPTPOLBALDH1A1TDP1 | |
| SCHEMBL5682845 | 0.71 | MAPT (0.55) | LMNAMAPTALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL8015744 | 0.69 | MAPT (0.66) | LMNAMAPTALDH1A1TDP1MAPK1 | |
| SCHEMBL8015787 | 0.68 | LMNA (0.48) | LMNAMAPTPOLBALDH1A1TDP1 | |
| SCHEMBL8019313 | 0.65 | MAPT (0.48) | LMNAMAPTPOLBALDH1A1TDP1 | |
| SCHEMBL1323030 | 0.65 | RAPGEF4 (0.65) | MAPTALDH1A1SMN1; SMN2RAPGEF4THRB | |
| SCHEMBL9786706 | 0.64 | MAPT (0.47) | LMNAMAPTPOLBALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130228-A | Polycyclic compounds | UNIVERSITY OF STRATHCLYDE (GB) | 2000-10-10 | — | — | US | disclosed |