Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
| ▸ | ACACB | O00763 | 5/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | PKLR | P30613 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26931991 | 0.79 | POLB (0.45) | GPR119USP2SMN1; SMN2ALOX15TSHR | |
| SCHEMBL25458288 | 0.78 | GPR119 (0.50) | GPR119NAMPTJAK1ALOX15TSHR | |
| SCHEMBL240381 | 0.78 | TSHR (0.57) | GPR119ALOX15TSHRATM | |
| SCHEMBL6041560 | 0.77 | GPR119 (0.51) | GPR119JAK1USP2SMN1; SMN2ALOX15 | |
| SCHEMBL2629481 | 0.77 | ALDH1A1 (0.60) | GPR119NAMPTSMN1; SMN2 | |
| SCHEMBL18432250 | 0.77 | ESR2 (0.48) | GPR119USP2SMN1; SMN2ALOX15TSHR | |
| SCHEMBL1815376 | 0.77 | GPR119 (0.45) | GPR119USP2SMN1; SMN2ALOX15TSHR | |
| SCHEMBL11956931 | 0.77 | GPR119 (0.53) | GPR119USP2SMN1; SMN2ALOX15TSHR | |
| SCHEMBL21143968 | 0.76 | DRD2 (0.46) | GPR119ACACBNAMPTJAK1USP2 | |
| SCHEMBL20744372 | 0.76 | JAK2 (0.46) | NAMPTJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000037074-A1 | MUTILIN 14-ESTER DERIVATIVES HAVING ANTIBACTERIAL ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2000-06-29 | — | — | WO | disclosed |