Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.47 |
| ▸ | MC4R | P32245 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8031455 | 0.92 | SIGMAR1 (0.53) | LMNAPOLBSIGMAR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8029654 | 0.88 | IGF1R (0.55) | LMNASIGMAR1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL5752956 | 0.88 | KDM4E (0.54) | SIGMAR1ALDH1A1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL8911301 | 0.86 | MEN1 (0.50) | LMNASIGMAR1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL8029639 | 0.81 | SIGMAR1 (0.50) | LMNAPOLBSIGMAR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8029891 | 0.80 | SIGMAR1 (0.50) | LMNASIGMAR1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL8029642 | 0.80 | SIGMAR1 (0.54) | LMNASIGMAR1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL8035814 | 0.79 | SIGMAR1 (0.49) | SIGMAR1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL8031421 | 0.79 | SIGMAR1 (0.48) | LMNAPOLBSIGMAR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7138408 | 0.78 | LTA4H (0.71) | MMP1MMP9MMP13ADAM17RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0702010-B1 | Benzopyranderivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-03-15 | — | — | EP | disclosed |
| US-5668138-A | AFFINITY FOR SIGMA RECEPTORS, CENTRAL NERVOUS SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1997-09-16 | — | — | US | disclosed |