Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | GHSR | Q92847 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8031455 | 0.88 | SIGMAR1 (0.53) | MEN1KMT2ASIGMAR1LMNAMMP1 | |
| SCHEMBL8020085 | 0.86 | LMNA (0.59) | MEN1KMT2ASIGMAR1LMNAMMP1 | |
| SCHEMBL8029654 | 0.85 | IGF1R (0.55) | MEN1KMT2ASIGMAR1LMNAMMP1 | |
| SCHEMBL5752956 | 0.85 | KDM4E (0.54) | MEN1KMT2ASIGMAR1KCNH2MMP1 | |
| SCHEMBL8033313 | 0.79 | KDM4E (0.58) | MEN1KMT2ASIGMAR1LMNAOPRK1 | |
| SCHEMBL8910223 | 0.79 | KMT2A (0.61) | MEN1KMT2ASIGMAR1LMNAKDM4E | |
| SCHEMBL8029639 | 0.78 | SIGMAR1 (0.50) | MEN1KMT2ASIGMAR1LMNAKDM4E | |
| SCHEMBL8029891 | 0.77 | SIGMAR1 (0.50) | MEN1KMT2ASIGMAR1LMNAMMP1 | |
| SCHEMBL8029642 | 0.77 | SIGMAR1 (0.54) | MEN1KMT2ASIGMAR1LMNAKCNH2 | |
| SCHEMBL8035814 | 0.76 | SIGMAR1 (0.49) | MEN1KMT2ASIGMAR1MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5668138-A | AFFINITY FOR SIGMA RECEPTORS, CENTRAL NERVOUS SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1997-09-16 | — | — | US | disclosed |