Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | LPL | P06858 | 1/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 5/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1363047 | 1.00 | USP30 (0.40) | USP30LPLLIPGMGLLPRMT5 | |
| SCHEMBL3399375 | 0.86 | LIPG (0.42) | LPLLIPGMGLLPTGDR2CCR1 | |
| SCHEMBL3399142 | 0.86 | LIPG (0.42) | LPLLIPGMGLLPTGDR2CCR1 | |
| SCHEMBL12062822 | 0.86 | LIPG (0.38) | LPLLIPGMGLLPTGDR2CCR1 | |
| SCHEMBL3041956 | 0.84 | GLS (0.47) | USP30LPLLIPGMGLLPRMT5 | |
| SCHEMBL29964482 | 0.84 | GLS (0.47) | USP30LPLLIPGMGLLPRMT5 | |
| SCHEMBL1632681 | 0.82 | POLB (0.47) | USP30MGLLNR1H2NR1H3GPR119 | |
| SCHEMBL19459436 | 0.80 | SETD7 (0.49) | USP30SETD7PDK1PDK2PDK3 | |
| SCHEMBL13954894 | 0.80 | PTGDR2 (0.52) | MGLLPTGDR2CCR1 | |
| SCHEMBL25425656 | 0.80 | LIPG (0.40) | LPLLIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100168-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009100166-A1 | DUAL PHARMACOPHORES-PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |