Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 6/20 | 0.68 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.68 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8579784 | 0.89 | ADORA1 (0.65) | ADORA2BADORA2AADORA1ADORA3MEN1 | |
| SCHEMBL8575318 | 0.89 | ADORA1 (0.65) | ADORA2BADORA2AADORA1ADORA3MEN1 | |
| SCHEMBL8579120 | 0.86 | ADORA1 (0.64) | ADORA2BADORA2AADORA1ADORA3MEN1 | |
| SCHEMBL787893 | 0.81 | ADORA2A (1.00) | ADORA2BADORA2AADORA1ADORA3MEN1 | |
| SCHEMBL8579881 | 0.81 | ADORA1 (0.62) | ADORA2BADORA2AADORA1ADORA3MEN1 | |
| SCHEMBL8118476 | 0.79 | ADORA1 (1.00) | ADORA2BADORA2AADORA1ADORA3MEN1 | |
| SCHEMBL9170264 | 0.79 | ADORA1 (0.62) | ADORA2BADORA2AADORA1ADORA3MEN1 | |
| SCHEMBL8355232 | 0.78 | ADORA3 (0.65) | ADORA2BADORA2AADORA1ADORA3MEN1 | |
| SCHEMBL5229734 | 0.78 | ADORA2B (1.00) | ADORA2BADORA2AADORA1ADORA3MEN1 | |
| SCHEMBL9645551 | 0.77 | ADORA1 (0.95) | ADORA2BADORA2AADORA1ADORA3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970696-A1 | Combination of loop diuretics with adenosine A1-receptor antagonists | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2000-01-12 | — | — | EP | claimed |
| EP-0970696-A1 | Combination of loop diuretics with adenosine A1-receptor antagonists | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2000-01-12 | — | — | EP | disclosed |