Demannose

Demannose

SCHEMBL8020533

C=C(C)C(=O)OCC.O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.39
TSHR P16473 4/20 0.38
CYP2D6 P10635 1/20 0.37
CYP2C19 P33261 1/20 0.37
GLO1 Q04760 1/20 0.34
ALDH1A1 P00352 3/20 0.33
PDE4A P27815 1/20 0.33
LMNA P02545 2/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
TDP1 Q9NUW8 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
USP2 O75604 1/20 0.31
SLCO1B1 Q9Y6L6 1/20 0.31
CASP1 P29466 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Demannose SCHEMBL14157347 1.00 THRB (0.39) THRBTSHRCYP2D6CYP2C19GLO1
Demannose SCHEMBL21274470 1.00 THRB (0.39) THRBTSHRCYP2D6CYP2C19GLO1
Demannose SCHEMBL15066411 0.88 GLO1 (0.40) CYP2D6CYP2C19GLO1ALDH1A1PDE4A
Demannose SCHEMBL5541835 0.84 LMNA (0.47) TSHRGLO1ALDH1A1PDE4ALMNA
Demannose SCHEMBL11509807 0.84 LMNA (0.47) TSHRGLO1ALDH1A1PDE4ALMNA
SCHEMBL4268327 0.81 TSHR (0.50) THRBTSHRALDH1A1
SCHEMBL4277422 0.81 TSHR (0.50) THRBTSHRALDH1A1
SCHEMBL4271272 0.81 TSHR (0.50) THRBTSHRALDH1A1
SCHEMBL4274441 0.81 TSHR (0.50) THRBTSHRALDH1A1
SCHEMBL1163840 0.81 TSHR (0.50) THRBTSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112601540-A Biopharmaceuticals for reducing lipid content in cells 约翰内斯堡威特沃特斯兰德大学 2021-04-02 CN claimed
CN-110769800-B Cosmetic composition containing fullerene 维生素C60生化学研究公司 2022-06-28 CN disclosed
CN-112601540-A Biopharmaceuticals for reducing lipid content in cells 约翰内斯堡威特沃特斯兰德大学 2021-04-02 CN disclosed
WO-2000040662-A1 COATING COMPOSITIONS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 2000-07-13 WO disclosed