Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 4/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.53 |
| ▸ | BMP1 | P13497 | 7/20 | 0.50 |
| ▸ | MMP13 | P45452 | 5/20 | 0.47 |
| ▸ | MMP1 | P03956 | 3/20 | 0.47 |
| ▸ | MMP8 | P22894 | 3/20 | 0.47 |
| ▸ | MMP7 | P09237 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 6/20 | 0.46 |
| ▸ | MMP2 | P08253 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6610164 | 0.91 | BMP1 (0.48) | KEAP1NFE2L2BMP1MMP13MMP1 | |
| SCHEMBL6608765 | 0.87 | KEAP1 (0.64) | KEAP1NFE2L2BMP1MMP13MMP1 | |
| SCHEMBL6608519 | 0.78 | MMP1 (0.55) | KEAP1NFE2L2BMP1MMP13MMP1 | |
| SCHEMBL5655796 | 0.78 | KEAP1 (0.56) | KEAP1NFE2L2BMP1MMP13MMP1 | |
| SCHEMBL6611402 | 0.76 | MMP1 (0.68) | KEAP1NFE2L2BMP1MMP13MMP1 | |
| SCHEMBL22252093 | 0.75 | KEAP1 (0.71) | KEAP1NFE2L2BMP1MMP13MMP1 | |
| SCHEMBL6609943 | 0.75 | MMP1 (0.47) | KEAP1NFE2L2BMP1MMP13MMP1 | |
| SCHEMBL22252350 | 0.73 | KEAP1 (0.74) | KEAP1NFE2L2BMP1MMP13MMP1 | |
| SCHEMBL8843343 | 0.70 | TAS2R14 (0.57) | KEAP1NFE2L2BMP1MMP13MMP1 | |
| SCHEMBL6609435 | 0.70 | KEAP1 (0.60) | KEAP1NFE2L2BMP1MMP13MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071903-A | ENZYME INHIBITORS OF MATRIX METALLOPROTEINASES (MMPS); ANTITUMOR,-CARCINOGENIC AND -ARTHRITIC AGENTS; OSTEOARTHRITIS; RHEUMATOID DISEASES; DEGENERATIVE CARTILAGE LOSS; LONG-ACTING, ORALLY BIOAVAILABLE NONPEPTIDE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-06-06 | — | — | US | disclosed |