Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8566958 | 0.92 | MTNR1A (0.41) | SIGMAR1ABCB1MTNR1ANQO2MTNR1B | |
| SCHEMBL8521248 | 0.92 | MTNR1A (0.41) | SIGMAR1ABCB1MTNR1ANQO2MTNR1B | |
| SCHEMBL8033089 | 0.83 | SIGMAR1 (0.42) | SIGMAR1ABCB1DRD2DRD4MTNR1A | |
| SCHEMBL8572116 | 0.82 | SIGMAR1 (0.64) | SIGMAR1ABCB1DRD2DRD4MTNR1A | |
| SCHEMBL18898091 | 0.82 | SIGMAR1 (0.64) | SIGMAR1ABCB1DRD2DRD4MTNR1A | |
| SCHEMBL8031506 | 0.81 | SIGMAR1 (0.41) | SIGMAR1ABCB1DRD2DRD4 | |
| SCHEMBL8035005 | 0.80 | SIGMAR1 (0.40) | SIGMAR1ABCB1DRD2 | |
| SCHEMBL18898255 | 0.79 | SIGMAR1 (0.41) | SIGMAR1ABCB1DRD2 | |
| SCHEMBL8035010 | 0.78 | MTNR1A (0.55) | MTNR1ANQO2MTNR1B | |
| SCHEMBL22389127 | 0.75 | KDM2B (0.42) | DRD2MTNR1ANQO2MTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745586-B1 | Aryl(alkyl) propylamides, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-03-08 | — | — | EP | disclosed |
| US-5760071-A | AN UREA OR THIOUREA COMPOUNDS FOR TREATING MELATONINERGIC SYSTEM DISORDER, SLEEP DISORDER | ADIR ET COMPAGNIE (FR) | 1998-06-02 | — | — | US | disclosed |
| US-5731352-A | THERAPY FOR DISORDERS OF THE MELATONINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1998-03-24 | — | — | US | disclosed |
| EP-0745586-A1 | Aryl(alkyl) propylamides, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-12-04 | — | — | EP | disclosed |