Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16242574 | 0.85 | POLB (0.68) | POLBMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL16242814 | 0.83 | POLB (0.65) | POLBMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL16351512 | 0.77 | CYP1A2 (0.45) | POLBMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL16242607 | 0.76 | POLB (0.57) | POLBMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL28346293 | 0.75 | ALDH1A1 (0.46) | MEN1KMT2ATAAR1IDO1CDC7 | |
| SCHEMBL19675345 | 0.74 | POLB (0.71) | POLBMEN1KMT2AMAPTNPSR1 | |
| Naphthalene SCHEMBL28721345 | 0.74 | MGAM (0.45) | MAPTTAAR1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL16242598 | 0.74 | POLB (0.87) | POLBMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL10665398 | 0.74 | TAAR1 (0.52) | MEN1KMT2ATAAR1IDO1CYP1A2 | |
| SCHEMBL5855074 | 0.73 | TAAR1 (0.50) | TAAR1IDO1CYP1A2CYP2C19CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6063779-A | CARDIOVASCULAR DISORDERS | MEIJI SEIKA KAISHA, LTD. (JP) | 2000-05-16 | — | — | US | disclosed |
| EP-0878475-A2 | 5-(4-Piperidinyl)dibenzothiazepine derivatives and 5-(4-piperidinyl)dibenzoxazepine derivatives, and antiarrhythmic agents | Meiji Seika Kaisha, Ltd. (JP) | 1998-11-18 | — | — | EP | disclosed |
| EP-0404359-B1 | Dibenzothiazepine derivatives useful as antispasmodic agents | PFIZER LTD (GB) | 1994-06-29 | — | — | EP | disclosed |
| US-5071844-A | Antispasmodic agents | PFIZER INC. (US) | 1991-12-10 | — | — | US | disclosed |
| EP-0404359-A1 | Dibenzothiazepine derivatives useful as antispasmodic agents | Pfizer Limited (GB) | 1990-12-27 | — | — | EP | disclosed |