Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.38 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | DRD1 | P21728 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | MC4R | P32245 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7074944 | 0.98 | CYP3A4 (0.41) | CYP3A4ALOX15CHRNB2NFKB1MAPK1 | |
| Iodide SCHEMBL3636049 | 0.96 | POLB (0.42) | CYP3A4ALOX15CHRNB2NFKB1MAPK1 | |
| SCHEMBL5281905 | 0.75 | APOBEC3A (0.37) | CYP3A4ALOX15CHRNB2NFKB1MAPK1 | |
| SCHEMBL5944513 | 0.73 | APOBEC3A (0.40) | CYP3A4ALOX15CHRNB2NFKB1MAPK1 | |
| SCHEMBL13223522 | 0.71 | SIRT6 (0.54) | MAPK1HSD17B10POLBMEN1KMT2A | |
| Acetamide SCHEMBL18425023 | 0.70 | MAPT (0.40) | HSD17B10POLBKMT2AHRH4 | |
| SCHEMBL15293601 | 0.70 | CYP1A2 (0.43) | CYP3A4ALOX15CHRNB2NFKB1MAPK1 | |
| SCHEMBL11163692 | 0.69 | HPGDS (0.34) | CYP3A4ALOX15CHRNB2NFKB1MAPK1 | |
| Acetamide SCHEMBL9275850 | 0.68 | HSD17B10 (0.39) | HSD17B10POLBMC4RMEN1KMT2A | |
| SCHEMBL7776562 | 0.68 | MC4R (0.48) | CYP3A4ALOX15CHRNB2NFKB1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000038673-A1 | COMPOSITIONS CONTAINING AND METHODS OF USING N-ACYL-1H-AMINOINDENES | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2000-07-06 | — | — | WO | disclosed |