SCHEMBL8022291

SCHEMBL8022291

CCC=C(C(=O)O)N(C)c1cccc(C(C)=NOC)c1

nearest known ligand 0.37

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 1/20 0.37
TSHR P16473 2/20 0.34
HSD17B2 P37059 1/20 0.34
PPARG P37231 7/20 0.34
PPARA Q07869 6/20 0.34
ALDH1A1 P00352 3/20 0.34
MAPT P10636 3/20 0.34
KDM4E B2RXH2 2/20 0.34
KMT2A Q03164 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
HPGD P15428 1/20 0.32
HSD17B10 Q99714 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8022288 0.86 HIF1A (0.36) HIF1ATSHRHSD17B2PPARGPPARA
SCHEMBL8500995 0.80 HIF1A (0.43) HIF1AHSD17B2ALDH1A1MAPTKDM4E
SCHEMBL8500992 0.78 HIF1A (0.42) HIF1AHSD17B2ALDH1A1MAPTKDM4E
SCHEMBL8500990 0.78 HIF1A (0.42) HIF1AHSD17B2ALDH1A1MAPTKDM4E
SCHEMBL8026232 0.72 HIF1A (0.39) HIF1AHSD17B2ALDH1A1MAPTKDM4E
SCHEMBL8020436 0.70 PPARG (0.48) HIF1APPARGPPARAKMT2AL3MBTL1
SCHEMBL8020470 0.69 L3MBTL1 (0.40) TSHRHSD17B2ALDH1A1MAPTKDM4E
SCHEMBL8020434 0.69 PPARG (0.47) HIF1APPARGPPARAL3MBTL1NPC1
SCHEMBL8020919 0.68 MAPT (0.38) HIF1AHSD17B2ALDH1A1MAPTKDM4E
SCHEMBL8021998 0.68 PPARG (0.48) HIF1APPARGPPARAL3MBTL1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0975587-A1 OXIME ETHER COMPOUNDS, THEIR USE AND INTERMEDIATES FOR PREPARATIONS OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2000-02-02 EP disclosed
WO-1998043949-A1 OXIME ETHER COMPOUNDS, THEIR USE AND INTERMEDIATES FOR PREPARATIONS OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-10-08 WO disclosed