Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17481227 | 0.86 | COMT (0.44) | COMTMAPTALDH1A1POLBHSD11B1 | |
| SCHEMBL12138136 | 0.84 | KMT2A (0.39) | COMTMAPTALDH1A1KMT2A | |
| SCHEMBL17298942 | 0.83 | COMT (0.40) | COMTMAPTALDH1A1POLBHSD11B1 | |
| SCHEMBL13868033 | 0.80 | COMT (0.38) | COMTMAPTALDH1A1POLB | |
| SCHEMBL25587144 | 0.80 | KMT2A (0.36) | KMT2A | |
| SCHEMBL12086420 | 0.77 | HPGD (0.37) | ALDH1A1KMT2A | |
| SCHEMBL23240255 | 0.75 | COMT (0.37) | COMTMAPTALDH1A1POLB | |
| SCHEMBL5174730 | 0.75 | COMT (0.46) | COMTMAPTALDH1A1POLBHSD11B1 | |
| SCHEMBL12086435 | 0.74 | APEX1 (0.31) | — | |
| SCHEMBL25111545 | 0.74 | F2RL3 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8927581-B2 | Fungicidal N-(2-pyridylpropyl) carboxamide derivatives and their oxa, aza and thia analogues | BAYER CROPSCIENCE AG (DE) | 2015-01-06 | — | — | US | disclosed |
| US-8841332-B2 | Fungicidal N-(2-phenoxyethyl)carboxamide derivatives and their aza, thia and sila analogues | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-09-23 | — | — | US | disclosed |
| US-20130261158-A1 | FUNGICIDAL N-(2-PHENOXYETHYL)CARBOXAMIDE DERIVATIVES AND THEIR AZA, THIA AND SILA ANALOGUES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-10-03 | — | — | US | disclosed |
| US-8507490-B2 | Tetrasubstituted pyridazine hedgehog pathway antagonists | ELI LILLY AND COMPANY (US) | 2013-08-13 | — | — | US | disclosed |
| US-8324133-B2 | Fungicide 2-pyridyl-methylene-carboxamide derivatives | BAYER CROPSCIENCE AG (DE) | 2012-12-04 | — | — | US | disclosed |
| US-8324133-B2 | Fungicide 2-pyridyl-methylene-carboxamide derivatives | BAYER CROPSCIENCE AG (DE) | 2012-12-04 | — | — | US | disclosed |
| US-20120071517-A1 | 2-PYRIDINYLETHYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS FUNGICIDES | BAYER SAS (FR) | 2012-03-22 | — | — | US | disclosed |
| US-20120071517-A1 | 2-PYRIDINYLETHYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS FUNGICIDES | BAYER SAS (FR) | 2012-03-22 | — | — | US | disclosed |
| US-20110263602-A1 | TETRASUBSTITUTED PYRIDAZINE HEDGEHOG PATHWAY ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-10-27 | — | — | US | disclosed |
| US-8026195-B2 | Fungicidal N-cycloalkyl-carboxamide derivatives | BAYER CROPSCIENCE AG (DE) | 2011-09-27 | — | — | US | disclosed |
| US-8026195-B2 | Fungicidal N-cycloalkyl-carboxamide derivatives | BAYER CROPSCIENCE AG (DE) | 2011-09-27 | — | — | US | disclosed |
| US-20110136874-A1 | FUNGICIDAL N-(2-PYRIDYLPROPYL) CARBOXAMIDE DERIVATIVES AND THEIR OXA, AZA AND THIA ANALOGUES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2011-06-09 | — | — | US | disclosed |
| US-7932283-B2 | Fungicide N-cyclopropyl-sulfonylamide derivatives | BAYER CROPSCIENCE AG (DE) | 2011-04-26 | — | — | US | disclosed |
| US-7932283-B2 | Fungicide N-cyclopropyl-sulfonylamide derivatives | BAYER CROPSCIENCE AG (DE) | 2011-04-26 | — | — | US | disclosed |
| US-20100010048-A1 | Fungicide 2-pyridyl-methylene-carboxamide derivatives | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2010-01-14 | — | — | US | disclosed |
| US-20100010048-A1 | Fungicide 2-pyridyl-methylene-carboxamide derivatives | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2010-01-14 | — | — | US | disclosed |
| US-20090326016-A1 | FUNGICIDAL N-CYCLOALKYL-CARBOXAMIDE DERIVATIVES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2009-12-31 | — | — | US | disclosed |
| US-20090326016-A1 | FUNGICIDAL N-CYCLOALKYL-CARBOXAMIDE DERIVATIVES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2009-12-31 | — | — | US | disclosed |
| US-20090137611-A1 | Fungicide N-Cyclopropyl-Sulfonylamide Derivatives | BAYER CROPSCIENCE AG (DE) | 2009-05-28 | — | — | US | disclosed |
| US-20090137611-A1 | Fungicide N-Cyclopropyl-Sulfonylamide Derivatives | BAYER CROPSCIENCE AG (DE) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071517-A1 | 2-PYRIDINYLETHYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS FUNGICIDES | CYP1A2, CYP51A1, CYP3A5 | COMT 3501/4885MAPT 1709/4885ALDH1A1 831/4885 |
| US-20110136874-A1 | FUNGICIDAL N-(2-PYRIDYLPROPYL) CARBOXAMIDE DERIVATIVES AND THEIR OXA, AZA AND THIA ANALOGUES | PNPO, AZI2, CYP51A1 | COMT 3400/4885MAPT 3504/4885ALDH1A1 1811/4885 |
| US-20100010048-A1 | Fungicide 2-pyridyl-methylene-carboxamide derivatives | CYP51A1, ME2, ME3 | COMT 1999/4885MAPT 2039/4885ALDH1A1 1267/4885 |
| US-20090137611-A1 | Fungicide N-Cyclopropyl-Sulfonylamide Derivatives | CYP51A1, ERG28, CBR3 | COMT 4494/4885MAPT 2939/4885ALDH1A1 2140/4885 |
| US-20090326016-A1 | FUNGICIDAL N-CYCLOALKYL-CARBOXAMIDE DERIVATIVES | CBR3, CBR1, CYCS | COMT 4169/4885MAPT 3996/4885ALDH1A1 1961/4885 |
| US-20130261158-A1 | FUNGICIDAL N-(2-PHENOXYETHYL)CARBOXAMIDE DERIVATIVES AND THEIR AZA, THIA AND SILA ANALOGUES | CYP51A1, TET3, CIP2A | COMT 2133/4885MAPT 3127/4885ALDH1A1 2072/4885 |
| US-20110263602-A1 | TETRASUBSTITUTED PYRIDAZINE HEDGEHOG PATHWAY ANTAGONISTS | SHH, SMO, GLI1 | COMT 4873/4885MAPT 4803/4885ALDH1A1 4107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.