Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 2/20 | 0.30 |
| ▸ | HTR2C | P28335 | 2/20 | 0.30 |
| ▸ | HTR2B | P41595 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL334828 | 0.82 | MEN1 (0.40) | ALDH1A1HTTSMN1; SMN2TRPA1TSHR | |
| SCHEMBL232609 | 0.82 | SLC5A2 (0.35) | ALDH1A1HTTSMN1; SMN2TSHRMEN1 | |
| SCHEMBL5604860 | 0.81 | NCF1 (0.44) | ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL6517254 | 0.81 | CHRNB4 (0.45) | ALDH1A1HTTSMN1; SMN2TSHR | |
| SCHEMBL6517744 | 0.81 | FOLH1 (0.38) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL11941052 | 0.81 | SMN1; SMN2 (0.49) | ALDH1A1HTTSMN1; SMN2LMNARAB9A | |
| SCHEMBL9520126 | 0.80 | SIGMAR1 (0.35) | ALDH1A1HTTSMN1; SMN2TSHRMEN1 | |
| SCHEMBL189832 | 0.79 | TRPA1 (0.38) | ALDH1A1TRPA1TSHR | |
| SCHEMBL6513629 | 0.79 | ALDH1A1 (0.36) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL9262464 | 0.79 | ALDH1A1 (0.39) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143170-B | For treating the aromatic compounds of pulmonary fibrosis, liver fibrosis, fibrosis of skin and cardiac fibrosis being substituted | 普罗米蒂克医药SMT有限公司 | 2019-11-08 | — | — | CN | disclosed |
| WO-2000049020-A2 | NOVEL EPOTHILON DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR PHARMACEUTICAL APPLICATION | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-08-24 | — | — | WO | disclosed |
| EP-0469833-B1 | N-Benzyl-Indoles, processes for their preparation and pharmaceutical compositions containing them | LILLY CO ELI (GB) | 1999-09-08 | — | — | EP | disclosed |
| US-5281593-A | Pharmaceuticals | LILLY INDUSTRIES LIMITED (GB) | 1994-01-25 | — | — | US | disclosed |
| EP-0469833-A1 | N-Benzyl-Indoles, processes for their preparation and pharmaceutical compositions containing them | LILLY INDUSTRIES LIMITED (GB) | 1992-02-05 | — | — | EP | disclosed |