Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15822716 | 0.76 | CTRC (0.40) | — | |
| SCHEMBL11567441 | 0.76 | ALDH1A1 (0.38) | ALDH1A1 | |
| SCHEMBL2153612 | 0.75 | CYP19A1 (0.48) | CYP19A1CA1CA2ALDH1A1SMN1; SMN2 | |
| SCHEMBL3232243 | 0.72 | GABRA1 (0.45) | — | |
| SCHEMBL28528207 | 0.71 | CYP19A1 (0.36) | CYP19A1CA1CA2ALDH1A1CTSB | |
| SCHEMBL8070651 | 0.70 | CYP19A1 (0.42) | CYP19A1CA1CA2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8023207 | 0.70 | KDM4E (0.41) | SMN1; SMN2MAPTKDM4E | |
| SCHEMBL8932159 | 0.69 | TDP1 (0.30) | — | |
| SCHEMBL28183864 | 0.68 | — | — | |
| SCHEMBL6208851 | 0.68 | GABRA1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0816356-B1 | 1-(2-(1-piperidinyl)-1-ethyl)-1,3-dihydro-2H-benzimidazole derivatives and their pharmaceutical use | LILLY CO ELI (GB) | 2000-11-02 | — | — | EP | disclosed |
| US-6075039-A | 5HT receptor binding benzimidazolylpiperidines | ELI LILLY AND COMPANY LIMITED (GB) | 2000-06-13 | — | — | US | disclosed |
| EP-0816356-A1 | 1-(2-(1-piperidinyl)-1-ethyl)-1,3-dihydro-2H-benzimidazole derivatives and their pharmaceutical use | ELI LILLY AND COMPANY LIMITED (GB) | 1998-01-07 | — | — | EP | disclosed |